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Disease Profile

Bacterial

Cronobacter invasive infection

克罗诺杆菌侵袭性感染

Cronobacter invasive infection is a bacterial invasive disease entity identified in the source record as primarily monitored in infants [1][2]. The available sources are limited to scholarly metadata and do not provide clinical, epidemiologic, or transmission detail beyond the disease title and its neonatal/infant surveillance context [1][2]. Source-backed detail on case patterns, exposure settings, and prevention measures is not yet available [1][2].

Definition

Cronobacter invasive infection is presented in the source material as an invasive bacterial infection associated with Cronobacter and as a subject of pediatric and neonatal public-health surveillance [1][2]. One source title specifies “invasive Cronobacter infection,” and another refers to “invasive neonatal Cronobacter (Enterobacter sakazakii) infections,” indicating that the organism has been discussed under both Cronobacter and the former name Enterobacter sakazakii in the cited literature [1][2]. No additional etiologic or syndromic characterization is provided in the supplied snippets [1][2].

Clinical features

The supplied sources do not describe the symptom pattern, anatomic sites of invasive disease, severity, course, or complications of Cronobacter invasive infection [1][2]. Although the disease is identified as invasive and the epidemiologic literature is framed around neonatal infection, the snippets do not specify manifestations such as bacteremia, meningitis, or other clinical outcomes, and those details should not be inferred [1][2]. Source-backed detail on clinical progression or prognosis is not yet available [1][2].

Epidemiology

The available metadata indicate that the epidemiology of invasive Cronobacter infection has been studied in neonatal populations, and that prevention-related work has involved epidemiologists, laboratorians, and public health agencies [1][2]. The disease is described in the disease record as primarily monitored in infants, but the supplied material does not provide geographic distribution, burden estimates, outbreak frequency, or reservoir information [1][2]. No source-backed data on age-specific incidence, seasonality, or specific exposure settings are included in the snippets [1][2].

Transmission

The supplied sources do not state a transmission route, vehicle, or exposure mechanism for invasive Cronobacter infection [1][2]. Because the evidence boundary is limited to article metadata and titles, no specific claims can be made about foodborne, environmental, household, or healthcare-associated transmission from these snippets alone [1][2]. Source-backed detail on acquisition pathways is not yet available [1][2].

Risk groups

The only clearly supported risk group in the supplied record is infants, with the epidemiologic literature also focusing on neonatal infection [1][2]. Beyond that, the snippets do not identify additional vulnerable populations, specific feeding exposures, prematurity, immune status, or care-setting risk factors, so these should not be added [1][2].

Prevention

One cited article is explicitly concerned with the roles of epidemiologists, laboratorians, and public health agencies in preventing invasive Cronobacter infection, showing that prevention has been approached as a public-health and laboratory collaboration issue [1]. However, the provided snippets do not specify particular control measures, product guidance, environmental interventions, or surveillance practices [1][2]. Source-backed detail on concrete prevention steps is not yet available [1][2].

Surveillance note

In surveillance terms, this entity should be read as a rare invasive bacterial infection that is especially relevant to infant and neonatal monitoring in the source record [1][2]. The available material supports a cautious, case-oriented interpretation centered on the organism name and the invasive/neonatal framing, but it does not support finer classification by syndrome, source, or outcome [1][2]. Source-backed detail on thresholds for reporting or outbreak detection is not yet available [1][2].

References
  1. 1 The Roles of Epidemiologists, Laboratorians, and Public Health Agencies in Preventing Invasive Cronobacter Infection. Frontiers in Pediatrics. 2015. doi: 10.3389/fped.2015.00110. DOI: https://doi.org/10.3389/fped.2015.00110
  2. 2 Epidemiology of invasive neonatal Cronobacter (Enterobacter sakazakii) infections. European Journal of Clinical Microbiology & Infectious Diseases. 2009. doi: 10.1007/s10096-009-0779-4. DOI: https://doi.org/10.1007/s10096-009-0779-4
Coding Register
ICD-10
ICD-11
Key Statistics
Total cases
0
Peak month
2024-01
Coverage
1 reporting countries · 2024-01-06 → 2026-06-20

Figure 1 | Full historical trajectories across all reporting countries.

Figure 2 | Year-over-year monthly comparison for seasonality and structural shifts.

Dataset Archive

Supplementary Data | Multi-country disease dataset

Machine-readable multi-country disease dataset (JSON/CSV) with source metadata.

Rows
129
Data Version
2026-06-20
Coverage
Included metadata
Source links, scope, cadence

Source Register

Official sources and update cadences used to construct the downloadable dataset.

US
US CDC NNDSSweeklyapi

United States

CDC National Notifiable Diseases Surveillance System provisional data.

Official source
Suggested presentation pattern: cite the data version and coverage window when exporting charts or tables for publication.