Decompression sickness is a disorder caused by bubbles that form when environmental pressure is reduced during decompression [1]. In the source material, it is distinguished from arterial gas embolism, which is a separate but related syndrome within decompression illness; decompression sickness is attributed specifically to in-situ bubble formation from dissolved inert gas [1]. The provided sources describe it as a syndrome with a constellation of symptoms following a change in ambient pressure [2].
Disease Profile
OtherDecompression sickness
减压病
Decompression sickness is a pressure-related syndrome within the broader category of decompression illness, caused by bubble formation after reduction in environmental pressure [1]. The term decompression illness also includes arterial gas embolism, whereas decompression sickness specifically refers to in-situ bubble formation from dissolved inert gas [1]. It is most relevant in contexts of changing ambient pressure, and the evidence base in the provided sources emphasizes risk factors, clinical variability, and hyperbaric oxygen as a therapeutic modality rather than detailed prevention schedules or screening pathways [2][3].
The documented clinical spectrum is broad, ranging from itching and minor pain to neurological symptoms, cardiac collapse, and death [1]. The review also indicates that decompression sickness can present as part of a larger decompression illness spectrum, with serious cases potentially leaving residual deficits even after several recompressions [1]. The available sources do not provide a detailed organ-system staging, specific symptom timelines, or a complete complication taxonomy beyond the severe outcomes noted here [1].
Reported settings include divers, compressed air workers, aviators, and astronauts, reflecting exposure to changing ambient pressure rather than person-to-person spread [1]. The source material also notes that arterial gas embolism within the decompression illness spectrum can arise from iatrogenic causes unrelated to decompression, but this is not presented as a feature of decompression sickness itself [1]. Risk is affected by immersion, exercise, and heat or cold, although the sources do not quantify incidence, geographic distribution, or outbreak burden [1]. Historical and review literature in the payload indicates ongoing scholarly attention to pathophysiology, risk factors, and long-term effects, but source-backed surveillance estimates are not yet available [2][4][5].
Decompression sickness is not described as infectious and has no person-to-person transmission route in the source material. It results from exposure to reduced environmental pressure leading to bubble formation from dissolved inert gas [1]. The relevant exposure contexts are pressure-change activities such as diving, compressed air work, aviation, and spaceflight [1].
Source-backed risk groups include divers, compressed air workers, aviators, and astronauts, all of whom encounter reductions in environmental pressure [1]. The review also indicates that risk is influenced by immersion, exercise, and heat or cold, but does not specify age, sex, or comorbidity-based risk stratification [1].
The provided sources do not give a detailed preventive schedule or operational protocol, so source-backed detail on prevention is limited. They do identify exposure-related risk modifiers, including immersion, exercise, and heat or cold, which may be relevant to risk reduction planning [1]. For established decompression illness, first aid is 100% oxygen and definitive treatment is recompression with breathing 100% oxygen, and the review also mentions adjunctive fluid administration and prophylaxis against venous thromboembolism in paralyzed patients [1].
In surveillance contexts, decompression sickness should be read as a pressure-exposure syndrome rather than an communicable disease event [1]. The source evidence supports attention to affected occupational and recreational groups exposed to changing pressure, and to severity ranging from minor cutaneous or pain symptoms to neurological compromise and death [1]. The literature cited here also notes a role for bubble monitoring and ongoing uncertainty about long-term effects, but the available payload does not provide standardized case definitions or reporting thresholds [2].
- 1 Vann RD et al. Decompression illness. Lancet. 2011 Jan 8. PMID: 21215883. doi: 10.1016/S0140-6736(10)61085-9. PubMed: https://pubmed.ncbi.nlm.nih.gov/21215883/
- 2 Decompression and Decompression Sickness. Comprehensive Physiology. 2014. doi: 10.1002/j.2040-4603.2014.tb00566.x. DOI: https://doi.org/10.1002/j.2040-4603.2014.tb00566.x
- 3 Sen S et al. Therapeutic effects of hyperbaric oxygen: integrated review. Med Gas Res. 2021 Jan-Mar. PMID: 33642335. doi: 10.4103/2045-9912.310057. PubMed: https://pubmed.ncbi.nlm.nih.gov/33642335/
- 4 Decompression: Decompression sickness. British Journal of Sports Medicine. 1986. doi: 10.1136/bjsm.20.2.50-a. DOI: https://doi.org/10.1136/bjsm.20.2.50-a
- 5 Decompression — Decompression Sickness. Scholarly DOI record. 1984. doi: 10.1007/978-3-662-02409-6. DOI: https://doi.org/10.1007/978-3-662-02409-6
- 6 Mitchell SJ et al. Decompression Sickness and Arterial Gas Embolism. N Engl J Med. 2022 Mar 31. PMID: 35353963. doi: 10.1056/NEJMra2116554. PubMed: https://pubmed.ncbi.nlm.nih.gov/35353963/
- T70.3
- NF04
Dataset Archive
Supplementary Data | Multi-country disease dataset
Machine-readable multi-country disease dataset (JSON/CSV) with source metadata.
