Exogenous poisoning refers to intoxication caused by an outside substance or agent, as reflected in the SINAN surveillance concept and in the cited literature on exogenous poisoning and related nephropathy [1][2]. The sources available for this brief are mostly scholarly metadata, so source-backed detail on specific toxicants, exposure thresholds, or pathophysiologic mechanisms is not yet available [1][2][4]. One cited article addresses acute exogenous poisoning in children and notes that poisonings may be unintentional or intentional [3].
Disease Profile
OtherExogenous poisoning
外源性中毒
Exogenous poisoning is a surveillance concept for intoxication arising from exposure to an external toxic agent, and the provided sources indicate it is used as a broad category rather than a single etiologic disease [1][2]. The available material is largely bibliographic and does not define a specific toxin, organ system, or clinical syndrome beyond poisoning as a public-health event [1][2]. In the child-health literature cited here, acute poisoning is described as an important childhood pathology and is classified as either unintentional or intentional, with intentional cases sometimes described as criminal or suicidal [3].
The source material does not provide a consolidated symptom profile, and source-backed detail on the typical clinical presentation of exogenous poisoning is not yet available [1][2][4]. One publication title indicates that renal involvement may occur in some cases, with a work specifically focused on nephropathy due to exogenous poisoning [2]. The available snippets do not describe severity range, time course, complications, or mortality pattern in enough detail to generalize beyond the citation context [1][2].
The epidemiologic information in the provided sources is limited, but one article states that acute poisoning plays an important role among childhood pathologies and ranks third among accidents, after street trauma and burns [3]. That same source identifies teenagers aged 14-15 years as a risk age group among patients with intentional poisonings [3]. Beyond this, source-backed detail on geographic distribution, surveillance burden, outbreak patterns, or dominant exposure settings is not yet available [1][2][4].
Exogenous poisoning is not transmitted person-to-person in the way an infectious disease is; the relevant exposure mechanism is contact with, ingestion of, or other exposure to an external toxic agent, but the provided sources do not specify the route for any particular poisoning type [1][2]. The available material does not support further detail on persistence, environmental reservoir, or secondary spread [1][2].
The only source-backed risk group explicitly identified in the provided material is adolescents aged 14-15 years among intentional poisoning cases [3]. The same source also notes that poisonings may be intentional or unintentional, but it does not provide additional demographic or occupational risk strata [3]. For other populations, source-backed detail is not yet available [1][2].
The source snippets do not provide specific preventive measures, and source-backed detail on exposure-control strategies is not yet available [1][2][4]. The classification of cases as unintentional or intentional suggests that prevention would need to address both accidental exposures and intentional harms, but the cited material does not specify interventions [3].
In surveillance, exogenous poisoning should be read as a broad toxic-exposure category rather than a single pathogen-specific disease entity, and the available sources indicate that it may include both accidental and intentional events [1][3]. The child-poisoning literature suggests that intentional cases deserve particular attention in adolescents aged 14-15 years, while other key contextual variables are not provided in the source set [3]. Because the evidence here is mainly bibliographic metadata, detailed case definitions, severity stratification, and exposure classification rules are not yet available from the snippets themselves [1][2][4].
- 1 Therapeutic apheresis in exogenous poisoning and in myeloma. Nephrology Dialysis Transplantation. 2001. doi: 10.1093/ndt/16.suppl_6.101. DOI: https://doi.org/10.1093/ndt/16.suppl_6.101
- 2 Nephropathy Due to Exogenous Poisoning. Sustainable Development Goals Series. 2025. doi: 10.1007/978-3-031-94777-3_5. DOI: https://doi.org/10.1007/978-3-031-94777-3_5
- 3 ACUTE EXOGENOUS POISONING IN CHILDREN. Health and Ecology Issues. 2015. doi: 10.51523/2708-6011.2015-12-1-12. DOI: https://doi.org/10.51523/2708-6011.2015-12-1-12
- 4 The role of exogenous histamine in scombroid poisoning. Toxicology Letters. 1979. doi: 10.1016/0378-4274(79)90037-7. DOI: https://doi.org/10.1016/0378-4274(79)90037-7
- 5 Wikidata contributors. Exogenous poisonings [Internet]. Wikidata. cited 20 May 2026. Available from: https://www.wikidata.org/wiki/Q69914655
- T36-T65
Figure 1 | Full historical trajectories across all reporting countries.
Figure 2 | Year-over-year monthly comparison for seasonality and structural shifts.
Dataset Archive
Supplementary Data | Multi-country disease dataset
Machine-readable multi-country disease dataset (JSON/CSV) with source metadata.
Source Register
Official sources and update cadences used to construct the downloadable dataset.
BR
Brazil DATASUS SINANmonthlyftp_dbc
Brazil
Brazil Ministry of Health DATASUS/SINAN public DBC microdata aggregated to national monthly notification counts.
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