Acute severe exogenous poisoning in this evidence refers to clinical states of acute intoxication addressed by extracorporeal detoxification, in which hemosorption using non-selective hemosorbents is described as a basic method comprising specific and non-specific therapeutic modalities that facilitate removal of toxicants of different nature from the human body [1].
Disease overview
OtherExogenous poisoning
外源性中毒
Evidence-backed informationEN 1/6 applicable sections · ZH 1/6 applicable sectionsUpdated Sep 3, 2026
Acute poisoning has been treated in approximately 5,000 patients with severe presentations using hemosorption (HS) employing non-selective hemosorbents as a core method combining both specific and non-specific therapeutic modalities that remove toxicants of varied chemical nature from the human body [1]. The addition of physico-chemical hemotherapy (magnetic, ultraviolet, and laser therapy, as well as indirect electrochemical blood oxidation by sodium hypochlorite) to HS has been shown to accelerate natural biotransformation of toxicants and to correct disturbed hemostasis, with a further significant increase in toxicant removal [1]. Combining HS with other afferent detoxification methods and physico-chemical hemotherapy improved detoxification therapy and reduced the department's mortality from 14.5% to 5.8%, a three-fold reduction [1].
Read the full clinical and epidemiological profile2
- 1Luzhnikov EA et al. [Retrospective view of the use of detoxifying hemosorption for the treatment of acute exogenous poisoning]. Vestn Ross Akad Med Nauk. 2009. PMID: 20000101.PubMed: https://pubmed.ncbi.nlm.nih.gov/20000101/
- T36-T65
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Official sourcesAuthority, cadence, notes1
Brazil DATASUS SINAN
Brazil
Brazil Ministry of Health DATASUS/SINAN public DBC microdata aggregated to national monthly notification counts.