Hantavirus pulmonary syndrome (HPS) is a hantaviral disease entity within the broader group of human infections caused by single-stranded RNA viruses in the Hantaviridae family [1]. It is identified in the supplied material as one of two acute febrile diseases associated with hantaviruses, alongside hemorrhagic fever with renal syndrome [1]. The available sources further describe HPS as environmentally acquired rather than detailing a person-to-person transmission model [2][1].
Disease Profile
Hantavirus pulmonary syndrome
汉他病毒肺症候群
Hantavirus pulmonary syndrome is a rare, environmentally acquired hantaviral infection and is described as an acute febrile disease in humans caused by hantaviruses in the Hantaviridae family [1]. Available source material characterizes it as a high-mortality condition and notes that an airway-centric imaging pattern is distinctly uncommon in this syndrome [2][1]. Source-backed detail on the full clinical course, specific exposures, and preventive measures is limited in the provided snippets [2][1].
The provided sources do not offer a full symptom list or staged clinical description, but they do indicate that HPS is associated with severe pneumonia and high mortality [2][1]. A radiologic airway-centric pattern, which is common in several other viral pneumonias, is stated to be distinctly uncommon in HPS [2][1]. No source-backed detail is available here regarding incubation period, prodromal features, respiratory progression, extrapulmonary manifestations, or complications beyond the general severity signal [2][1].
Hantaviruses are described as a significant and emerging global public health threat, with more than 200,000 individuals affected worldwide each year [1]. Within that broader burden, HPS is described as a rare infection with high mortality [2][1]. The supplied snippets do not specify regional distribution, seasonality, reservoir species, outbreak settings, or other ecological details for HPS, so those features are not yet source-backed in this brief [2][1].
The available sources support an environmental acquisition context for HPS, but they do not specify the precise route of exposure in the supplied snippets [2][1]. No source-backed detail is available on whether transmission is linked to inhalation, contact, occupational exposure, or other mechanisms, so these points are omitted here [2][1].
The supplied sources do not identify specific demographic or occupational risk groups for HPS. They do note that community-acquired viral pathogens can cause more severe pneumonia in immunocompromised hosts, but this statement is general to viral pneumonias and is not specific evidence for HPS risk stratification [2][1].
The supplied material does not provide specific preventive measures for HPS, and it does not identify a licensed vaccine or globally licensed treatment for hantavirus infection [1]. On that evidence base, only the absence of licensed vaccine availability can be stated confidently; further exposure-control recommendations are not source-backed in the provided snippets [1].
In surveillance interpretation, HPS should be read as a rare but high-severity hantaviral syndrome with environmentally acquired infection and substantial public-health significance [2][1]. Its distinction from more typical community-acquired viral pneumonias is supported by the note that an airway-centric pattern is distinctly uncommon in HPS [2][1]. The provided sources do not supply case definitions, confirmatory testing criteria, or reporting thresholds, so those details are not included [2][1].
- 1 Febbo J et al. Viral Pneumonias. Infect Dis Clin North Am. 2024 Mar. PMID: 38280762. doi: 10.1016/j.idc.2023.12.009. PubMed: https://pubmed.ncbi.nlm.nih.gov/38280762/
- 2 Febbo J et al. Viral Pneumonias. Radiol Clin North Am. 2022 May. PMID: 35534126. doi: 10.1016/j.rcl.2022.01.010. PubMed: https://pubmed.ncbi.nlm.nih.gov/35534126/
- 3 Afzal S et al. Hantavirus: an overview and advancements in therapeutic approaches for infection. Front Microbiol. 2023. PMID: 37901807. doi: 10.3389/fmicb.2023.1233433. PubMed: https://pubmed.ncbi.nlm.nih.gov/37901807/
- 4 Hantavirus Pulmonary Syndrome. Red Book: 2024–2027 Report of the Committee on Infectious Diseases. 2024. doi: 10.1542/9781610027359-s3_008_002. DOI: https://doi.org/10.1542/9781610027359-s3_008_002
- 5 Hantavirus Pulmonary Syndrome. Community-Acquired Pneumonia. 2002. doi: 10.1007/0-306-46834-4_40. DOI: https://doi.org/10.1007/0-306-46834-4_40
- 6 Hantavirus Pulmonary Syndrome. Red Book: 2024–2027 Report of the Committee on Infectious Diseases. 2024. doi: 10.1542/9781610027373-s3_008_002. DOI: https://doi.org/10.1542/9781610027373-s3_008_002
- B33.4
- 1D64
Dataset Archive
Supplementary Data | Multi-country disease dataset
Machine-readable multi-country disease dataset (JSON/CSV) with source metadata.
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