Severe fever with thrombocytopenia syndrome is a life-threatening emerging infectious disease caused by SFTS virus, a novel phlebovirus in the Bunyaviridae family.[3][4][2]
Disease overview
SFTS
发热伴血小板减少综合征
Evidence-backed informationEN 3/7 applicable sections · ZH 3/7 applicable sectionsUpdated Sep 3, 2026
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne hemorrhagic fever caused by SFTS virus, a phlebovirus in the Bunyaviridae family. It occurs mainly in East Asia, particularly China, Japan, and South Korea, although the vector tick has spread beyond the region.[1][2] Clinical manifestations commonly include fever, thrombocytopenia, leukopenia, gastrointestinal symptoms, and central nervous system involvement; reported case-fatality rates vary substantially across studies.[3][2]
Read the full clinical and epidemiological profile4
The major clinical manifestations are fever, thrombocytopenia, leukopenia, gastrointestinal symptoms, and central nervous system manifestations.[3][2] Bleeding tendency, central nervous system manifestations, elevated serum enzymes, and high viral load are associated with severe disease or fatality; older age is also reported as a risk factor for poor outcome.[3]
SFTS is an emerging tick-borne zoonosis reported mainly in China, Japan, and South Korea, with the disease first described in rural areas of China.[1][2] In China, approximately 2,500 cases across 11 provinces had been reported since 2010, with an average case-fatality rate of 7.3% in one review.[2] Other reviews report case-fatality rates up to 30% or 50% depending on the included studies and case mix, while a pooled analysis of laboratory-confirmed cases estimated 16%.[3][1][5]
- 1Dualis H et al. Factors and outcomes in Severe Fever with Thrombocytopenia Syndrome (SFTS): A systematic review. Ann Med Surg (Lond). 2021 Jul. PMID: 34188913. doi: 10.1016/j.amsu.2021.102501.PubMed: https://pubmed.ncbi.nlm.nih.gov/34188913/
- 2Liu Q et al. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis. 2014 Aug. PMID: 24837566. doi: 10.1016/S1473-3099(14)70718-2.PubMed: https://pubmed.ncbi.nlm.nih.gov/24837566/
- 3Liu MM et al. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J. 2016 Nov 29. PMID: 27899121. doi: 10.1186/s12985-016-0661-9.PubMed: https://pubmed.ncbi.nlm.nih.gov/27899121/
- 4Woo D et al. Transmission of Severe Fever with Thrombocytopenia Syndrome (SFTS) to humans: A systematic review of individual participant data and meta-analysis. J Infect Public Health. 2025 Jun. PMID: 40073663. doi: 10.1016/j.jiph.2025.102685.PubMed: https://pubmed.ncbi.nlm.nih.gov/40073663/
- 5Kim D et al. Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development. Viruses. 2024 Jan 16. PMID: 38257828. doi: 10.3390/v16010128.PubMed: https://pubmed.ncbi.nlm.nih.gov/38257828/
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Coverage
Reporting countries and regions
Trends by reporting country
Monthly patterns over time
Data access
Page dataset index with source links and update metadata.
Official sourcesAuthority, cadence, notes5
China CDC Weekly
China
Monthly notifiable infectious disease reports published by China CDC.
National Disease Control and Prevention Administration
China
Official China public health bulletin and query portal.
PubMed
China
Biomedical literature discovery feed used as supplementary context.
JP NIID Weekly
Japan
Japan weekly infectious disease surveillance via NIID/JIHS.
Korea KDCA EID
South Korea
Korea KDCA notifiable infectious disease OpenAPI or portal/KOSIS downloads aggregated to national monthly notification counts.