The entity 'syphilis in pregnancy' is defined within the Brazil DATASUS SINAN registry as a national notification and investigation concept for syphilis identified during pregnancy, with provenance recorded as a SINAN surveillance concept [3]. It corresponds to a treponemal infection in pregnant individuals that may be acquired sexually, hematogenously, or passed vertically to the fetus [1].
Disease overview
Bacterial Evidence-backed information EN 1/6 applicable sections · ZH 1/6 applicable sections Updated Oct 23, 2026
Syphilis in pregnancy is a treponemal infection that can be transmitted vertically from mother to infant and remains a growing public health threat with rising prevalence in recent years [1]. In the United States, congenital syphilis rates increased substantially from 2013 to 2018 and continued to rise through 2021, while global incidence has also climbed, particularly in low- and middle-income regions [2][1]. The Brazil Ministry of Health maintains this condition as a notifiable entity within its national SINAN surveillance system [3].
Read the full clinical and epidemiological profile 2
- 1 Eppes CS et al. Syphilis in pregnancy: an ongoing public health threat. Am J Obstet Gynecol. 2022 Dec. PMID: 35932881. doi: 10.1016/j.ajog.2022.07.041. PubMed: https://pubmed.ncbi.nlm.nih.gov/35932881/
- 2 Salomè S et al. Congenital Syphilis: A Re-Emerging but Preventable Infection. Pathogens. 2024 Jun 6. PMID: 38921779. doi: 10.3390/pathogens13060481. PubMed: https://pubmed.ncbi.nlm.nih.gov/38921779/
- 3 Brazil Ministry of Health SINAN. SINAN registry entity: Syphilis in pregnancy [Internet]. cited 23 Oct 2026. Available from: https://www.gov.br/saude/pt-br/composicao/svsa/sistemas-de-informacao/sinan
- A50-A53
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Research Radar
Recent related research
Syphilis Screening in Pregnancy During Emergency Department Gonorrhea and Chlamydia Testing
Western Journal of Emergency Medicine
Global Estimates of Syphilis in Pregnancy and Associated Adverse Outcomes: Analysis of Multinational Antenatal Surveillance Data
PLoS Medicine
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