https://globalinfectiousdisease.com/research/ Published infectious-disease literature filtered to Chagas disease. en Wed, 09 Sep 2026 07:02:01 GMT https://globalinfectiousdisease.com/research/articles/10-1093-trstmh-trag097-2f6c7451/ https://globalinfectiousdisease.com/research/articles/10-1093-trstmh-trag097-2f6c7451/ Thu, 20 Aug 2026 00:00:00 GMT The disconnect between maternal detection and neonatal treatment reveals a fractured care chain for congenital Chagas disease in Mexico. The authors identify urgent need for universal prenatal screening and standardized molecular diagnostics at birth to fulfill Pan American Health Organization Elimination Initiative commitments. Chagas disease Transmission dynamics Diagnostics Treatment Systematic review https://globalinfectiousdisease.com/research/articles/10-1073-pnas-2600647123-7781bea6/ https://globalinfectiousdisease.com/research/articles/10-1073-pnas-2600647123-7781bea6/ Mon, 17 Aug 2026 00:00:00 GMT Findings point to a vector-side mechanism that supports gut homeostasis after blood feeding and is exploited by T. cruzi, with potential relevance to Chagas disease transmission biology. Chagas disease Journal article https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014622-c018e003/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014622-c018e003/ Wed, 12 Aug 2026 00:00:00 GMT The findings suggest NK cell dysregulation in chronic Chagas disease may contribute to cardiac pathology through uncontrolled cytotoxic responses against persistent parasites, while benznidazole treatment may help restore NK cell balance. Chagas disease Treatment Journal article https://globalinfectiousdisease.com/research/articles/10-1186-s12879-026-13565-3-2bd53b71/ https://globalinfectiousdisease.com/research/articles/10-1186-s12879-026-13565-3-2bd53b71/ Wed, 17 Jun 2026 00:00:00 GMT By establishing uniform evaluation criteria and mapping financial requirements, the report aims to accelerate the deployment of accessible testing instruments that align with regional elimination timelines. Chagas disease Diagnostics Health policy Treatment Guideline https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013917-da549cac/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013917-da549cac/ Tue, 20 Jan 2026 00:00:00 GMT The proposed metabolomics-based counter-screening approach could be implemented early in Chagas' disease drug discovery workflows to prioritize compounds with novel mechanisms of action, addressing the urgent need for new treatments. Chagas disease Treatment Journal article https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013811-212a2603/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013811-212a2603/ Mon, 08 Dec 2025 00:00:00 GMT The findings indicate that infected vectors may engage in adaptive behavioral fever suppression (anapyrexia) that reduces parasite development. This has potential implications for understanding Chagas disease transmission ecology and designing vector control interventions that account for insect behavior. Chagas disease Transmission dynamics Climate and environment Journal article https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013199-12ffe081/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0013199-12ffe081/ Thu, 31 Jul 2025 00:00:00 GMT The validated distribution models identify areas of suitable habitat for Chagas disease vectors in the domestic cycle, providing information to support epidemiological control efforts and improve surveillance strategies in Hidalgo, Mexico. Chagas disease Surveillance Transmission dynamics Climate and environment Journal article https://globalinfectiousdisease.com/research/articles/10-1016-s2666-5247-24-00110-1-73fbab18/ https://globalinfectiousdisease.com/research/articles/10-1016-s2666-5247-24-00110-1-73fbab18/ Sun, 01 Sep 2024 00:00:00 GMT The authors framed early detection and treatment of congenital Chagas disease in mothers and newborns as a public health priority and suggested that, if validated more broadly, the simpler PrintrLab-LAMP workflow could support decentralised diagnostic access. Chagas disease Transmission dynamics Diagnostics Treatment Journal article https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0011003-dbad51b5/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0011003-dbad51b5/ Wed, 14 Dec 2022 00:00:00 GMT Urban Chagas disease represents an emerging challenge that adds complexity to disease control due to distinct characteristics of urban lifestyles and agglomerations. The shift from rural to urban vector transmission requires adaptation of existing vector control programs. Chagas disease Transmission dynamics Climate and environment Systematic review https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0001207-738911f4/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0001207-738911f4/ Tue, 21 Jun 2011 00:00:00 GMT Community participation should become a strategic component of Chagas disease surveillance. Only professional insecticide spraying appears consistently effective at eliminating infestation foci, and stakeholder involvement throughout the process would likely strengthen participation-based strategies. Chagas disease Surveillance Transmission dynamics Climate and environment Systematic review