https://globalinfectiousdisease.com/research/ Published infectious-disease literature filtered to Case-control study. en Wed, 09 Sep 2026 07:02:01 GMT https://globalinfectiousdisease.com/research/articles/10-3389-fimmu-2026-1908452-606ef91e/ https://globalinfectiousdisease.com/research/articles/10-3389-fimmu-2026-1908452-606ef91e/ Mon, 24 Aug 2026 00:00:00 GMT The findings suggest that inflammatory and iron metabolism biomarkers may help stratify COVID-19 severity and identify mechanisms underlying disease progression, including persistent pathology in severe long COVID-19. COVID-19 Vaccination Case-control study https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2026-106719-705b2901/ https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2026-106719-705b2901/ Wed, 01 Apr 2026 00:00:00 GMT The documented high protection rate suggests utility for national immunization programs aiming to reduce severe bacterial enteric disease in endemic regions. Typhoid fever Vaccination Vaccine effectiveness Treatment Surveillance Case-control study https://globalinfectiousdisease.com/research/articles/10-1038-s41467-026-71094-8-c913ca6c/ https://globalinfectiousdisease.com/research/articles/10-1038-s41467-026-71094-8-c913ca6c/ Tue, 31 Mar 2026 00:00:00 GMT The findings identify a perturbed T cell compartment in acute rheumatic fever and provide a mechanistic rationale for exploring currently available immune-modulating therapies to treat the disease and prevent progressive cardiac damage. Rheumatic fever Case-control study https://globalinfectiousdisease.com/research/articles/10-3390-vaccines14020164-205efd10/ https://globalinfectiousdisease.com/research/articles/10-3390-vaccines14020164-205efd10/ Tue, 10 Feb 2026 00:00:00 GMT The documentation underscores the value of immunization strategies in reducing severe disease outcomes within affected communities. Regional variations in coverage indicate opportunities for targeted outreach initiatives to improve community protection. Tick-borne encephalitis Vaccination Vaccine effectiveness Climate and environment Case-control study https://globalinfectiousdisease.com/research/articles/10-1038-s41591-025-03998-9-b96e01f9/ https://globalinfectiousdisease.com/research/articles/10-1038-s41591-025-03998-9-b96e01f9/ Tue, 07 Oct 2025 00:00:00 GMT Findings from the abstract suggest Rotavac provided substantial protection against severe rotavirus disease under programmatic conditions in India, including against non-vaccine strains, and was characterized as performing comparably to internationally licensed vaccines in similar settings. Gastroenteritis SARS COVID-19 Vaccination Vaccine effectiveness Surveillance Case-control study https://globalinfectiousdisease.com/research/articles/10-1016-j-ahjo-2025-100630-7f7211ab/ https://globalinfectiousdisease.com/research/articles/10-1016-j-ahjo-2025-100630-7f7211ab/ Mon, 29 Sep 2025 00:00:00 GMT Findings are relevant to the lack of specific diagnostic tests for acute rheumatic fever and rheumatic heart disease in low-resource settings, where these diseases impose the greatest burden. Rheumatic fever Diagnostics Case-control study https://globalinfectiousdisease.com/research/articles/10-1111-irv-70023-87fbe51b/ https://globalinfectiousdisease.com/research/articles/10-1111-irv-70023-87fbe51b/ Mon, 02 Dec 2024 00:00:00 GMT Continued emphasis on seasonal immunization remains critical for safeguarding vulnerable demographics and pediatric cohorts. Public health initiatives should persist in highlighting documented protective outcomes to sustain coverage rates among eligible groups. Influenza Vaccination Vaccine effectiveness Surveillance Case-control study https://globalinfectiousdisease.com/research/articles/10-1093-eurpub-ckae144-1924-adff930a/ https://globalinfectiousdisease.com/research/articles/10-1093-eurpub-ckae144-1924-adff930a/ Mon, 28 Oct 2024 00:00:00 GMT Sustaining routine immunization initiatives appears capable of reducing outpatient utilization for influenza-related illnesses, with notably stronger protective signals observed when administering live attenuated formulations to school-aged youth. Influenza Vaccination Vaccine effectiveness Surveillance Case-control study https://globalinfectiousdisease.com/research/articles/10-1186-s12879-024-09932-7-50219630/ https://globalinfectiousdisease.com/research/articles/10-1186-s12879-024-09932-7-50219630/ Fri, 27 Sep 2024 00:00:00 GMT The findings highlight the need to increase vaccination coverage with diphtheria-containing vaccines through routine immunization and tetanus-diphtheria vaccination for childbearing-age females. Community awareness regarding protective measures during home care of diphtheria cases is recommended. Investigation of vaccination service delivery and gender barriers related to tetanus-diphtheria vaccination is warranted. Diphtheria Tetanus Vaccination Outbreak investigation Climate and environment Travel medicine Case-control study https://globalinfectiousdisease.com/research/articles/10-1038-s41541-024-00960-7-38d314c4/ https://globalinfectiousdisease.com/research/articles/10-1038-s41541-024-00960-7-38d314c4/ Fri, 13 Sep 2024 00:00:00 GMT The findings support vaccination strategies by demonstrating that despite modest increases in post-vaccination thromboembolic risk, the overall effect of mRNA COVID-19 vaccination reduces thromboembolic event burden through prevention of infection-associated events, with greater benefit during high transmission periods. COVID-19 SARS Vaccination Outbreak investigation Vaccine effectiveness Case-control study https://globalinfectiousdisease.com/research/articles/10-2807-1560-7917-es-2024-29-18-2300558-9973be5c/ https://globalinfectiousdisease.com/research/articles/10-2807-1560-7917-es-2024-29-18-2300558-9973be5c/ Thu, 02 May 2024 00:00:00 GMT The findings support vaccination recommendations by demonstrating that even young children can experience severe TBE and that complete vaccination provides durable protection against neurological disease for at least 10 years. Tick-borne encephalitis Surveillance Vaccination Vaccine effectiveness Case-control study https://globalinfectiousdisease.com/research/articles/10-1056-nejmoa2215201-466804dd/ https://globalinfectiousdisease.com/research/articles/10-1056-nejmoa2215201-466804dd/ Thu, 29 Jun 2023 00:00:00 GMT The findings support the usefulness of JYNNEOS vaccination against mpox disease and suggest greater protection with completion of the two-dose series, relevant to U.S. outbreak control among at-risk adults. Monkeypox Smallpox HIV infection AIDS Vaccination Vaccine effectiveness Outbreak investigation Case-control study https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0010982-aa90c595/ https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0010982-aa90c595/ Mon, 12 Dec 2022 00:00:00 GMT The study is relevant to understanding invasive Salmonella transmission in a household and One Health context in Malawi. It also highlights the value of household sampling for transmission-oriented epidemiology and the challenge of detecting S. Typhi from the environment. Typhoid fever Transmission dynamics Climate and environment One Health Case-control study https://globalinfectiousdisease.com/research/articles/10-1038-s41467-022-33378-7-3e9beeac/ https://globalinfectiousdisease.com/research/articles/10-1038-s41467-022-33378-7-3e9beeac/ Fri, 30 Sep 2022 00:00:00 GMT The findings demonstrate that incidental hospital admissions with Omicron may lead to underestimation of vaccine protection against severe disease, emphasizing the need for precise case definitions in vaccine effectiveness surveillance. COVID-19 SARS Vaccination Vaccine effectiveness Diagnostics Case-control study https://globalinfectiousdisease.com/research/articles/10-1038-s41591-021-01446-y-de6639e9/ https://globalinfectiousdisease.com/research/articles/10-1038-s41591-021-01446-y-de6639e9/ Fri, 09 Jul 2021 00:00:00 GMT The findings demonstrate high vaccine effectiveness against variants of concern and severe outcomes, supporting vaccination efforts during periods of variant circulation. COVID-19 SARS Vaccination Vaccine effectiveness Treatment Case-control study https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciy1096-9c81d32a/ https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciy1096-9c81d32a/ Sun, 23 Dec 2018 00:00:00 GMT The documented protective outcomes reinforce the utility of oral rotavirus immunizations in regions experiencing elevated pediatric mortality. These findings may assist public health authorities in evaluating immunization adoption strategies for comparable epidemiological environments. Gastroenteritis Vaccination Vaccine effectiveness Surveillance Treatment Case-control study https://globalinfectiousdisease.com/research/articles/10-2807-1560-7917-es-2017-22-44-17-00306-d17fed69/ https://globalinfectiousdisease.com/research/articles/10-2807-1560-7917-es-2017-22-44-17-00306-d17fed69/ Thu, 02 Nov 2017 00:00:00 GMT These results bolster the rationale for sustaining youth immunization initiatives while underscoring the continued necessity of developing robust protective strategies for elderly populations. Influenza Vaccination Surveillance Diagnostics Vaccine effectiveness Case-control study https://globalinfectiousdisease.com/research/articles/10-3201-eid2103-140896-a6c0c970/ https://globalinfectiousdisease.com/research/articles/10-3201-eid2103-140896-a6c0c970/ Sun, 01 Mar 2015 00:00:00 GMT Controlling tuberculosis in prison settings is critical for reducing disease prevalence in the broader community, as prisons may serve as reservoirs for community transmission. Tuberculosis Surveillance Transmission dynamics Treatment Climate and environment Case-control study https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2014-06-022-87a47e0a/ https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2014-06-022-87a47e0a/ Sat, 01 Nov 2014 00:00:00 GMT The report is relevant to foodborne outbreak investigation and transmission dynamics in a university setting. It describes a norovirus-associated outbreak linked to a food source and a possibly infected food handler. Gastroenteritis Outbreak investigation Transmission dynamics Climate and environment Case-control study https://globalinfectiousdisease.com/research/articles/10-1093-cid-cis761-71642628/ https://globalinfectiousdisease.com/research/articles/10-1093-cid-cis761-71642628/ Tue, 20 Nov 2012 00:00:00 GMT The work addresses diarrheal disease, cited as one of the top two causes of young child mortality in the developing world, and aims to inform prioritization of water/sanitation, hygiene, and vaccine strategies. Gastroenteritis Treatment Vaccination Surveillance Transmission dynamics Case-control study https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2012-05-024-3c82bb18/ https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2012-05-024-3c82bb18/ Sun, 01 Jul 2012 00:00:00 GMT The authors emphasize that findings support improved strategies to reduce missed vaccination opportunities and achieve high nationwide measles vaccination coverage to prevent large outbreaks and advance measles mortality reduction. Measles Vaccination Outbreak investigation Vaccine effectiveness Surveillance Case-control study