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  <title>GIDS Research Radar · Antimicrobial resistance</title>
  <link>https://globalinfectiousdisease.com/research/</link>
  <description>Published infectious-disease literature filtered to Antimicrobial resistance.</description>
  <language>en</language>
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  <lastBuildDate>Wed, 09 Sep 2026 07:02:01 GMT</lastBuildDate>
  <item>
    <title>Targeting Latent Tuberculosis Using Hypoxia-Activated Prodrugs of Bedaquiline Analogues</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1021-acsmedchemlett-6c00238-c0b06aeb/</link>
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    <pubDate>Fri, 04 Sep 2026 00:00:00 GMT</pubDate>
    <description>The findings address antimicrobial resistance and limited treatment options for latent tuberculosis infection, which affects approximately 90% of infected individuals. The hypoxia-activated prodrug approach may improve treatment of persistent tuberculosis within hypoxic niches that drive prolonged treatment regimens.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Multidrug-resistant and virulent Streptococcus suis strains detected in clinically healthy pigs in Guangdong and Guangxi, China</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s13567-026-01832-9-b01f1d2d/</link>
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    <pubDate>Sat, 29 Aug 2026 00:00:00 GMT</pubDate>
    <description>The authors frame the combination of pathogenicity, multidrug resistance, and horizontal gene transfer potential via ICEs and prophages as a serious public health risk from healthy pig-derived S. suis, calling for enhanced surveillance.</description>
    <category>Streptococcus suis</category>
    <category>Surveillance</category>
    <category>Antimicrobial resistance</category>
    <category>One Health</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Melioidosis in South Asia: Scientific Advances, Regional Challenges and One Health Perspectives—An Integrated Research Synthesis from the 4th South Asian Melioidosis Congress</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-12688-wellcomeopenres-27378-1-ded6c4b1/</link>
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    <pubDate>Fri, 21 Aug 2026 00:00:00 GMT</pubDate>
    <description>The compilation frames melioidosis as an escalating yet frequently ignored infectious threat that demands improved monitoring frameworks, uniform testing standards, and interdisciplinary coordination to decrease adverse health outcomes.</description>
    <category>Melioidosis</category>
    <category>Tuberculosis</category>
    <category>One Health</category>
    <category>Surveillance</category>
    <category>Outbreak investigation</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Climate and environment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Changes in the clinical distribution and antibiotic resistance of Klebsiella pneumoniae in a tertiary hospital before and after the COVID-19 pandemic</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-026-14277-4-5dc193bf/</link>
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    <pubDate>Thu, 20 Aug 2026 00:00:00 GMT</pubDate>
    <description>The findings are positioned to inform antibiotic stewardship and hospital infection control by highlighting temporal shifts in K. pneumoniae epidemiology and resistance patterns around the pandemic transition.</description>
    <category>COVID-19</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13 Vibrio cholerae lineages driving cholera outbreaks in Tanzania (2022–2024)</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1099-mgen-0-001813-f29b2d9a/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1099-mgen-0-001813-f29b2d9a/</guid>
    <pubDate>Tue, 18 Aug 2026 00:00:00 GMT</pubDate>
    <description>Results inform public health interventions by clarifying transmission dynamics and antimicrobial resistance patterns relevant to treatment strategies. The authors emphasize the necessity for enhanced national and cross-border genomic surveillance to manage control efforts effectively.</description>
    <category>Cholera</category>
    <category>Genomic epidemiology</category>
    <category>Surveillance</category>
    <category>Outbreak investigation</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Next-Generation Sequencing in Melioidosis: Enhancing Diagnosis, Epidemiology and Antimicrobial Resistance Surveillance</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-3390-diagnostics16162613-f3b98a75/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-3390-diagnostics16162613-f3b98a75/</guid>
    <pubDate>Tue, 18 Aug 2026 00:00:00 GMT</pubDate>
    <description>Incorporating these genomic methodologies into standard care pathways may strengthen disease control efforts and optimize therapeutic decision-making, particularly in underserved regions.</description>
    <category>Melioidosis</category>
    <category>Surveillance</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Climate and environment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Artificial intelligence and machine learning applications in abdominal tuberculosis diagnosis: A scoping review and translational roadmap</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-35712-aig-123751-6bffb915/</link>
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    <pubDate>Tue, 18 Aug 2026 00:00:00 GMT</pubDate>
    <description>Improving detection accuracy for abdominal tuberculosis in resource-constrained environments could mitigate diagnostic delays and support more standardized care delivery pathways.</description>
    <category>Tuberculosis</category>
    <category>AIDS</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Efektivitas Penggunaan Obat Antibiotik pada Pasien Demam &lt;i&gt;Typhoid&lt;/i&gt;</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-67865-wp6f3871-cd79ddf8/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-67865-wp6f3871-cd79ddf8/</guid>
    <pubDate>Tue, 18 Aug 2026 00:00:00 GMT</pubDate>
    <description>Assessing these treatment metrics addresses documented concerns regarding therapeutic failure, mortality risks, and potential antimicrobial resistance development.</description>
    <category>Typhoid fever</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Climate and environment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Advanced lesions of tuberculosis of the genitourinary system</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-54921-2413-0346-2026-14-1-29-35-2ea347e4/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-54921-2413-0346-2026-14-1-29-35-2ea347e4/</guid>
    <pubDate>Sat, 15 Aug 2026 00:00:00 GMT</pubDate>
    <description>The findings highlight that advanced genitourinary tuberculosis is common and strongly associated with disseminated respiratory disease, drug resistance, and HIV-negative status, which may inform screening and treatment protocols.</description>
    <category>Tuberculosis</category>
    <category>HIV infection</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Burden of Shigella infection in children under five years living in a peri-urban area of Ouagadougou, Burkina Faso: A community-based cohort study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014624-0abee3ac/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014624-0abee3ac/</guid>
    <pubDate>Fri, 14 Aug 2026 00:00:00 GMT</pubDate>
    <description>Regional incidence estimates and strain distributions offer foundational parameters for evaluating pediatric immunization strategies and directing sanitation resource allocation.</description>
    <category>Shigellosis</category>
    <category>Dysentery</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Vaccination</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Cohort study</category>
  </item>
  <item>
    <title>Molecularepidemiology and antimicrobial resistance determinants of Corynebacterium diphtheriae causing infections in Karachi, Pakistan, 2023-2024</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2026-109058-27663fab/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2026-109058-27663fab/</guid>
    <pubDate>Sat, 01 Aug 2026 00:00:00 GMT</pubDate>
    <description>The widespread presence of resistant strains and genetic diversity suggests that local infection control strategies and laboratory testing protocols may require updates to address emerging transmission patterns.</description>
    <category>Diphtheria</category>
    <category>Tetanus</category>
    <category>COVID-19</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Genomic epidemiology</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Vaccination</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Qualification of a high-throughput luminescence-based Serum Bactericidal Activity assay to assess the functionality of human sera against five Shigella serotypes</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2026-128965-8a57192f/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2026-128965-8a57192f/</guid>
    <pubDate>Sat, 01 Aug 2026 00:00:00 GMT</pubDate>
    <description>The study provides an assay method for evaluating functional antibody responses during development of Shigella vaccines. The abstract places this work in the context of shigellosis burden and antimicrobial-resistance concerns, but it does not report clinical effectiveness, disease reduction, or population-level outcomes.</description>
    <category>Dysentery</category>
    <category>Shigellosis</category>
    <category>Vaccination</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Dual inhibition of respiratory complexes in &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; results in bacterial killing.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1128-spectrum-00643-26-352b15ae/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1128-spectrum-00643-26-352b15ae/</guid>
    <pubDate>Mon, 13 Jul 2026 00:00:00 GMT</pubDate>
    <description>The identification of synergistic metabolic vulnerabilities provides a foundation for developing combination treatments aimed at overcoming antimicrobial resistance in tuberculosis infections.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-s1473-3099-26-00227-6-2767a2bd/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-s1473-3099-26-00227-6-2767a2bd/</guid>
    <pubDate>Wed, 01 Jul 2026 00:00:00 GMT</pubDate>
    <description>The abstract frames sexually transmissible shigellosis as a public health concern requiring interventions beyond traditional enteric-disease measures. It also highlights antimicrobial stewardship as relevant across pathogens in a syndemic setting.</description>
    <category>Shigellosis</category>
    <category>Antimicrobial resistance</category>
    <category>Genomic epidemiology</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Treatment</category>
    <category>Travel medicine</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Physicians’ perspectives on the perceived increase in respiratory infections post-COVID-19 in Pakistan: a qualitative study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-026-13677-w-e05bc575/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-026-13677-w-e05bc575/</guid>
    <pubDate>Wed, 03 Jun 2026 00:00:00 GMT</pubDate>
    <description>The reported trends underscore requirements for enhanced diagnostic capacity, coordinated immunization efforts, and tighter medication regulation to manage worsening respiratory disease loads.</description>
    <category>COVID-19</category>
    <category>SARS</category>
    <category>Vaccination</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Climate and environment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Identification and drug resistance profiling of &lt;i&gt;Mycobacterium orygis&lt;/i&gt; from an African elephant using whole-genome sequencing.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1128-spectrum-03586-25-7d367107/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1128-spectrum-03586-25-7d367107/</guid>
    <pubDate>Thu, 07 May 2026 00:00:00 GMT</pubDate>
    <description>Documenting this rare tuberculosis complex variant in a captive species highlights the necessity for refined diagnostic protocols and precise antimicrobial testing. The authors propose that coordinated monitoring of affected wildlife facilities and associated personnel may help limit potential cross-species spread.</description>
    <category>Tuberculosis</category>
    <category>Genomic epidemiology</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>One Health</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Salmonellosis in Poultry: Study of Its Spread and The Effectiveness of Antibiotics Against It</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-55640-gjmps-volume05issue05-03-c5792c21/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-55640-gjmps-volume05issue05-03-c5792c21/</guid>
    <pubDate>Fri, 01 May 2026 00:00:00 GMT</pubDate>
    <description>The elevated resistance rates to conventional treatments underscore the importance of enhanced farm biosecurity and prudent antibiotic stewardship to limit resistance accumulation in food animal environments.</description>
    <category>Salmonellosis</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Development of Thieno[2,3-b]pyridin-6(7H)-one derivatives against drug-resistant Mycobacterium tuberculosis.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-bmc-2026-118663-7542126a/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-bmc-2026-118663-7542126a/</guid>
    <pubDate>Sat, 11 Apr 2026 00:00:00 GMT</pubDate>
    <description>The compounds represent potential hit candidates for developing novel antitubercular agents effective against drug-resistant tuberculosis, addressing a critical need for new therapeutic options.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Genomic epidemiology and evolutionary dynamics of Bordetella pertussis: A comparative study between China and Global Strains (2018–2024)</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2026-108397-8cc21dd3/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2026-108397-8cc21dd3/</guid>
    <pubDate>Wed, 01 Apr 2026 00:00:00 GMT</pubDate>
    <description>The convergence of resistance, hypervirulence, and potential vaccine escape within a dominant lineage is framed by the authors as grounds to revisit antibiotic stewardship and pertussis vaccination strategies.</description>
    <category>Pertussis</category>
    <category>Genomic epidemiology</category>
    <category>Antimicrobial resistance</category>
    <category>Surveillance</category>
    <category>Vaccination</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Artesunate–pyronaridine–atovaquone–proguanil and artesunate–fosmidomycin–clindamycin compared with standard artesunate–pyronaridine for the treatment of uncomplicated malaria (MultiMal): a randomised, controlled, clinical, phase 2 trial in Gabon and Ghana</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101245-4f0f82f3/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101245-4f0f82f3/</guid>
    <pubDate>Sun, 01 Mar 2026 00:00:00 GMT</pubDate>
    <description>The authors position APAP and AFC as candidate multidrug combinations intended to address emerging artemisinin-reduced susceptibility in sub-Saharan Africa, warranting further clinical development.</description>
    <category>Malaria</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Randomised controlled trial</category>
  </item>
  <item>
    <title>Bedaquiline resistance in patients with Xpert MTB/RIF Ultra-tested rifampicin-resistant tuberculosis in the Western Cape, South Africa: a prospective study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101293-2e1d7dc7/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101293-2e1d7dc7/</guid>
    <pubDate>Sun, 01 Mar 2026 00:00:00 GMT</pubDate>
    <description>Authors emphasize the necessity of prioritizing systematic monitoring for resistance to maintain effective treatment protocols. Elevated resistance levels in certain subgroups underscore the importance of updated diagnostic and therapeutic approaches.</description>
    <category>Tuberculosis</category>
    <category>Surveillance</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Cohort study</category>
  </item>
  <item>
    <title>Future Prospects for Using Clinical Phenotypes in Tuberculosis Precision Medicine—An Approach for Clinical Management</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciaf663-c98d790b/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciaf663-c98d790b/</guid>
    <pubDate>Thu, 15 Jan 2026 00:00:00 GMT</pubDate>
    <description>Shorter treatment regimens that prevent drug resistance development and achieve relapse-free cure would reduce treatment burden and improve tuberculosis control, particularly in high-endemic settings where many proposed monitoring tools are suitable.</description>
    <category>Tuberculosis</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciaf524-e49868e5/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1093-cid-ciaf524-e49868e5/</guid>
    <pubDate>Thu, 08 Jan 2026 00:00:00 GMT</pubDate>
    <description>These projections inform strategic planning for managing resistance risks associated with upcoming therapeutic approvals for sexually transmitted infections.</description>
    <category>Gonorrhea</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Mathematical modelling</category>
  </item>
  <item>
    <title>Drivers of delay in tuberculosis diagnosis among underserved groups in Portugal: An exploratory convergent parallel mixed-methods study.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1080-25310429-2026-2720832-39c9b1b5/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1080-25310429-2026-2720832-39c9b1b5/</guid>
    <pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
    <description>The abstract frames diagnostic delay as relevant to tuberculosis control in Portugal, particularly for underserved populations. It links reducing delays with preventable morbidity, ongoing transmission, health inequities, and progress toward TB targets.</description>
    <category>Tuberculosis</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Syndromic cholera diagnosis masks diverse causes of diarrhoeal disease in Burundi revealed by portable metagenomics.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014175-f55fe056/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1371-journal-pntd-0014175-f55fe056/</guid>
    <pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
    <description>The findings demonstrate that syndromic cholera diagnosis can miss diverse diarrheal etiologies. Mobile metagenomic sequencing may improve etiological resolution and outbreak response in resource-limited settings where diagnostic capacity is constrained.</description>
    <category>Cholera</category>
    <category>Outbreak investigation</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006–2015)</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11913-3-efc4836a/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11913-3-efc4836a/</guid>
    <pubDate>Mon, 17 Nov 2025 00:00:00 GMT</pubDate>
    <description>The findings provide genomic context for XDR-TB resistance-associated variation in the studied Argentine isolates. The authors state that the results support continued research and surveillance efforts, but the abstract does not quantify population-level effects or clinical outcomes.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Surveillance</category>
    <category>Genomic epidemiology</category>
    <category>Treatment</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Haemophilus influenzae global epidemiology and antimicrobial susceptibility patterns including ampicillin and amoxicillin-clavulanate resistance based on β-lactamase production, 2013–2022</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11438-9-fe5e80e6/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11438-9-fe5e80e6/</guid>
    <pubDate>Thu, 23 Oct 2025 00:00:00 GMT</pubDate>
    <description>The findings indicate geographic variation in H. influenzae antimicrobial resistance and differences associated with beta-lactamase production. The authors state that these results support reliable susceptibility testing and resistance-containment efforts, while the abstract reports caution regarding clarithromycin in settings with high resistance.</description>
    <category>Haemophilus influenzae</category>
    <category>Antimicrobial resistance</category>
    <category>Surveillance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Temporal and geographic trends in extended-spectrum cephalosporins resistance among Neisseria gonorrhoeae isolates worldwide: a systematic review and meta-analysis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11601-2-156ec51e/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-025-11601-2-156ec51e/</guid>
    <pubDate>Mon, 29 Sep 2025 00:00:00 GMT</pubDate>
    <description>The findings highlight the critical public health challenge posed by emerging antibiotic resistance in gonococcal infections and emphasize the need for antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems.</description>
    <category>Syphilis</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Selecting candidate Neisseria gonorrhoeae strains for oropharyngeal gonorrhoea human challenge: a genomics-based analysis of clinical isolates</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101105-dd3c0aac/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-lanmic-2025-101105-dd3c0aac/</guid>
    <pubDate>Mon, 01 Sep 2025 00:00:00 GMT</pubDate>
    <description>The work supports development of a controlled human infection model that could accelerate novel gonorrhoea prevention and therapeutic strategies, addressing a pathogen of major public health concern due to rising prevalence and antimicrobial resistance. The selection approach prioritizes participant safety and identifies strains relevant for evaluating current and future vaccines.</description>
    <category>Gonorrhea</category>
    <category>Gonococcal infection</category>
    <category>Antimicrobial resistance</category>
    <category>Transmission dynamics</category>
    <category>Treatment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia.</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-jgar-2025-07-017-4637b665/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-jgar-2025-07-017-4637b665/</guid>
    <pubDate>Tue, 22 Jul 2025 00:00:00 GMT</pubDate>
    <description>The findings indicate that some resistance-associated mutations or deletions identified in this sample may not be detected by routine diagnostic methods described by the authors. The abstract also states that known resistance mutations could be assessed using Xpert MTB/XDR together with Xpert MTB/RIF, while rapid methods for detecting resistance to newer drugs remain needed.</description>
    <category>Tuberculosis</category>
    <category>Genomic epidemiology</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1038-s41467-025-59922-9-3e9a4829/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1038-s41467-025-59922-9-3e9a4829/</guid>
    <pubDate>Fri, 16 May 2025 00:00:00 GMT</pubDate>
    <description>The findings characterize resistance-relevant hotspots in PL pro that may inform the design of next-generation inhibitors, with potential relevance to antiviral preparedness against SARS-CoV-2.</description>
    <category>SARS</category>
    <category>COVID-19</category>
    <category>Antimicrobial resistance</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Genomic epidemiology and antimicrobial resistance reveal local transmission dynamics of enteric fever in Shenzhen, one of the mega cities in China</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2025-106469-c4631148/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2025-106469-c4631148/</guid>
    <pubDate>Tue, 01 Apr 2025 00:00:00 GMT</pubDate>
    <description>Mapping these genetic and resistance patterns assists authorities in anticipating spread routes and prioritizing monitoring efforts in densely populated regions.</description>
    <category>Typhoid fever</category>
    <category>Paratyphoid fever</category>
    <category>Outbreak investigation</category>
    <category>Antimicrobial resistance</category>
    <category>Genomic epidemiology</category>
    <category>Transmission dynamics</category>
    <category>Surveillance</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2025-106421-400490db/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2025-106421-400490db/</guid>
    <pubDate>Sat, 01 Mar 2025 00:00:00 GMT</pubDate>
    <description>The supplied abstract identifies multidrug-resistant Salmonella Enteritidis clades associated with reported gastroenteritis outbreaks and invasive disease in China. It describes implications for monitoring bacterial population changes and for further genomic epidemiological investigation, but does not establish causal effects or quantify risk beyond the studied isolates.</description>
    <category>Gastroenteritis</category>
    <category>Genomic epidemiology</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Surveillance</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>The molecular bacterial load assay predicts treatment responses in patients with pre-XDR/XDR-tuberculosis more accurately than GeneXpert Ultra MTB/Rif</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2024-106399-1ce73fa4/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2024-106399-1ce73fa4/</guid>
    <pubDate>Sat, 01 Feb 2025 00:00:00 GMT</pubDate>
    <description>Early detection of treatment failure is critical for improving drug-resistant tuberculosis management. MBLA demonstrated superior early identification of successful culture conversion compared to existing tests and may serve as a useful biomarker for evaluating novel anti-tuberculosis agents in early-phase clinical trials.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Cohort study</category>
  </item>
  <item>
    <title>Comprehensive review of salmonellosis: current status of the disease and future perspectives</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-4081-ijfs-2024-12904-3f0193ba/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-4081-ijfs-2024-12904-3f0193ba/</guid>
    <pubDate>Tue, 01 Oct 2024 00:00:00 GMT</pubDate>
    <description>The manuscript underscores the considerable disease burden in the region and delineates strategic interventions aimed at curbing transmission through coordinated policy adjustments and resource allocation.</description>
    <category>Salmonellosis</category>
    <category>Surveillance</category>
    <category>Vaccination</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990–2021: findings from the Global Burden of Disease Study 2021</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s40249-024-01230-3-5696923f/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s40249-024-01230-3-5696923f/</guid>
    <pubDate>Fri, 16 Aug 2024 00:00:00 GMT</pubDate>
    <description>HIV-TB co-infection represents a major global public health challenge. The findings suggest that improved diagnostic and treatment strategies, strengthened healthcare infrastructure, increased access to quality care, and enhanced public health education are needed to address this co-infection.</description>
    <category>Tuberculosis</category>
    <category>AIDS</category>
    <category>Multidrug-resistant tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Health policy</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea: A systematic review of WGS use on human pathogens in individual patient care</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2024-106168-6f8b0a8b/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-jinf-2024-106168-6f8b0a8b/</guid>
    <pubDate>Sat, 01 Jun 2024 00:00:00 GMT</pubDate>
    <description>The review suggests that whole genome sequencing may offer insights into pathogen transmission within sexual networks, enabling more targeted patient management for sexually transmitted infections. However, evidence remains limited to a small number of studies with few participants.</description>
    <category>Tuberculosis</category>
    <category>Gonorrhea</category>
    <category>Genomic epidemiology</category>
    <category>Outbreak investigation</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Ceftriaxone-Resistant Gonorrhea — China, 2022</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-15585-mmwr-mm7312a2-110d0a68/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-15585-mmwr-mm7312a2-110d0a68/</guid>
    <pubDate>Thu, 28 Mar 2024 00:00:00 GMT</pubDate>
    <description>The substantial increase in ceftriaxone resistance threatens gonorrhea treatment effectiveness in China, where gonorrhea ranked as the fourth most common notifiable infectious disease in 2022 with 96,313 reported cases. Effective diagnosis, treatment, and partner management are essential to prevent transmission of resistant strains.</description>
    <category>Gonorrhea</category>
    <category>Syphilis</category>
    <category>Tuberculosis</category>
    <category>Viral Hepatitis</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2023-11-010-fa8cc9af/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2023-11-010-fa8cc9af/</guid>
    <pubDate>Mon, 01 Jan 2024 00:00:00 GMT</pubDate>
    <description>The findings support the value of whole genome sequencing for identifying clusters and resistance mutations in low-burden settings, which can inform contact tracing, surveillance, and treatment strategies for drug-resistant TB.</description>
    <category>Tuberculosis</category>
    <category>Genomic epidemiology</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Surveillance</category>
    <category>Treatment</category>
    <category>Cohort study</category>
  </item>
  <item>
    <title>Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-s2666-5247-23-00172-6-4080c24a/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-s2666-5247-23-00172-6-4080c24a/</guid>
    <pubDate>Fri, 01 Dec 2023 00:00:00 GMT</pubDate>
    <description>The findings demonstrate substantial bedaquiline-resistance gain in programmatically treated patients and provide evidence of bedaquiline-resistant strain transmission. The authors emphasize that routine drug susceptibility testing should urgently accompany scale-up of novel tuberculosis drugs, though rapid testing remains challenging due to genetic variant diversity.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Transmission dynamics</category>
    <category>Treatment</category>
    <category>Cohort study</category>
  </item>
  <item>
    <title>Diabetes mellitus affects the treatment outcomes of drug-resistant tuberculosis: a systematic review and meta-analysis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-023-08765-0-e9809e7f/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-023-08765-0-e9809e7f/</guid>
    <pubDate>Mon, 20 Nov 2023 00:00:00 GMT</pubDate>
    <description>The findings suggest that diagnosing diabetes in drug-resistant and multidrug-resistant tuberculosis patients is important, and that glucose control and therapeutic monitoring during treatment may improve outcomes. The intersection of tuberculosis and diabetes represents a challenge for tuberculosis control programs globally.</description>
    <category>Tuberculosis</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Health policy</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Genomic epidemiology and multilevel genome typing of Bordetella pertussis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1080-22221751-2023-2239945-cb60ceb1/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1080-22221751-2023-2239945-cb60ceb1/</guid>
    <pubDate>Wed, 02 Aug 2023 00:00:00 GMT</pubDate>
    <description>Pertussis causes severe respiratory infection in infants and has resurged in industrialised countries despite vaccination, partly due to pathogen adaptation. Antimicrobial resistance has also emerged. The developed MGT system provides a scalable approach for global surveillance to understand public health risks posed by circulating and emerging strains.</description>
    <category>Pertussis</category>
    <category>Vaccination</category>
    <category>Genomic epidemiology</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Antimicrobial resistance</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Update of drug-resistant tuberculosis treatment guidelines: A turning point</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2023-03-013-84db036f/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2023-03-013-84db036f/</guid>
    <pubDate>Mon, 01 May 2023 00:00:00 GMT</pubDate>
    <description>The updated guidelines establish a shorter, all-oral, and more patient-centered approach to MDR/RR-TB management, potentially improving treatment acceptability and equity.</description>
    <category>Tuberculosis</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Health policy</category>
    <category>Guideline</category>
  </item>
  <item>
    <title>Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-cmi-2022-12-006-5942f2ce/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-cmi-2022-12-006-5942f2ce/</guid>
    <pubDate>Wed, 01 Mar 2023 00:00:00 GMT</pubDate>
    <description>Monitoring pathogen adaptation during large-scale viral emergencies underscores the necessity of robust clinical oversight mechanisms. Maintaining rigorous hygiene protocols and drug management frameworks appears critical for containing resistant bacterial spread.</description>
    <category>COVID-19</category>
    <category>SARS</category>
    <category>Antimicrobial resistance</category>
    <category>Outbreak investigation</category>
    <category>Surveillance</category>
    <category>Transmission dynamics</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Impact of molecular diagnostic tests on diagnostic and treatment delays in tuberculosis: a systematic review and meta-analysis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-022-07855-9-d1469a28/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-022-07855-9-d1469a28/</guid>
    <pubDate>Wed, 14 Dec 2022 00:00:00 GMT</pubDate>
    <description>WHO-recommended molecular diagnostics reduce delays in diagnosing and initiating tuberculosis treatment, which may improve patient outcomes and reduce transmission in high-burden settings.</description>
    <category>Tuberculosis</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Estimating the contribution of transmission in primary healthcare clinics to community-wide TB disease incidence, and the impact of infection prevention and control interventions, in KwaZulu-Natal, South Africa</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1136-bmjgh-2021-007136-90531e37/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1136-bmjgh-2021-007136-90531e37/</guid>
    <pubDate>Fri, 08 Apr 2022 00:00:00 GMT</pubDate>
    <description>The findings indicate that primary healthcare clinics may contribute to community tuberculosis burden in the modeled setting and that clinic infection-prevention measures could have effects beyond healthcare workers and patients. These implications are model-based estimates for the study community and period, not observed outcome measurements.</description>
    <category>Tuberculosis</category>
    <category>Transmission dynamics</category>
    <category>Climate and environment</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Value of routine whole genome sequencing for Mycobacterium tuberculosis drug resistance detection</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2021-03-033-6121ffe9/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-ijid-2021-03-033-6121ffe9/</guid>
    <pubDate>Wed, 01 Dec 2021 00:00:00 GMT</pubDate>
    <description>The abstract frames routine sequencing as relevant to tuberculosis drug resistance detection and management in low-incidence settings. The article is indexed to tuberculosis, antimicrobial resistance, and genomic epidemiology topics.</description>
    <category>Tuberculosis</category>
    <category>Genomic epidemiology</category>
    <category>Antimicrobial resistance</category>
    <category>Genomic study</category>
  </item>
  <item>
    <title>Efficacy of bedaquiline in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1186-s12879-021-06666-8-a4b3500e/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1186-s12879-021-06666-8-a4b3500e/</guid>
    <pubDate>Fri, 17 Sep 2021 00:00:00 GMT</pubDate>
    <description>Drug-resistant tuberculosis remains a major public health concern worldwide. The findings suggest bedaquiline has the potential to improve outcomes among drug-resistant tuberculosis cases.</description>
    <category>Tuberculosis</category>
    <category>Multidrug-resistant tuberculosis</category>
    <category>Treatment</category>
    <category>Antimicrobial resistance</category>
    <category>Systematic review</category>
  </item>
  <item>
    <title>Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2021-04-018-605da262/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-j-vaccine-2021-04-018-605da262/</guid>
    <pubDate>Thu, 01 Jul 2021 00:00:00 GMT</pubDate>
    <description>The authors argue that vaccination could be the most cost-effective and equitable primary prevention approach for ETEC, complementing water, sanitation, and clinical care, particularly in low- and middle-income settings where need is greatest.</description>
    <category>Gastroenteritis</category>
    <category>Vaccination</category>
    <category>Climate and environment</category>
    <category>Antimicrobial resistance</category>
    <category>Treatment</category>
    <category>Health policy</category>
    <category>Journal article</category>
  </item>
  <item>
    <title>Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance</title>
    <link>https://globalinfectiousdisease.com/research/articles/10-1016-s1473-3099-20-30847-1-a19bd53e/</link>
    <guid isPermaLink="true">https://globalinfectiousdisease.com/research/articles/10-1016-s1473-3099-20-30847-1-a19bd53e/</guid>
    <pubDate>Tue, 01 Jun 2021 00:00:00 GMT</pubDate>
    <description>The article provides a framework for more consistent case characterization and treatment decisions for COVID-19-associated pulmonary aspergillosis, including consideration of azole resistance. The supplied evidence does not quantify disease burden, treatment effects, or mortality.</description>
    <category>COVID-19</category>
    <category>SARS</category>
    <category>Health policy</category>
    <category>Antimicrobial resistance</category>
    <category>Diagnostics</category>
    <category>Treatment</category>
    <category>Guideline</category>
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