Siglec-1-targeted nanobodies restrict HIV-1 transmission and infection of dendritic cells
Journal of Virology·
- DOI
- 10.1128/jvi.00128-26
- PMID
- 42523118
- PMCID
- —
- OpenAlex
- W7171721589
- Study type
- Journal article
- Publisher
- American Society for Microbiology
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The data indicate that interfering with host attachment molecules could theoretically disrupt initial viral dissemination pathways, supporting continued exploration of such mechanisms.
Structured evidence summary
Research question
Does neutralizing the Siglec-1 receptor with engineered nanobodies prevent dendritic cells from capturing and transferring HIV-1?
Study design
An in vitro laboratory experiment assessing the binding interference and cellular impact of single-domain antibody fragments across modified cell lines and dendritic cultures.
Population and setting
The investigation relies exclusively on cultured cell systems rather than human subjects or in vivo models.
Main findings
Targeted nanobodies successfully inhibited viral attachment and subsequent infection in receptor-overexpressing models. Application to dendritic cells stopped both replication-dependent and independent viral transfer while avoiding unintended immune stimulation.
Public-health relevance
The data indicate that interfering with host attachment molecules could theoretically disrupt initial viral dissemination pathways, supporting continued exploration of such mechanisms.
Important limitations
The evaluation relies solely on in vitro cell culture systems, meaning physiological complexity, systemic pharmacokinetics, and human safety remain unaddressed.
GIDS interpretation
This manuscript documents preclinical validation of a receptor-specific inhibitory agent, offering background reference for scholarly assessments of host-targeted antiviral development.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.