HIV-1 pretreatment drug resistance and genetic transmission network in the southwest border region of China
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-022-07734-3
- PMID
- —
- PMCID
- —
- OpenAlex
- W4296251708
- Study type
- Cross-sectional study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The authors frame pretreatment resistance, especially NNRTI resistance, as relevant to antiretroviral treatment planning and ongoing surveillance in this border prefecture. The article is also indexed under surveillance, transmission dynamics, and treatment topics, which supports its public-health and epidemiologic context.
Structured evidence summary
Research question
To assess pretreatment HIV-1 drug resistance and describe the associated genetic transmission network in Pu'er Prefecture, southwest Yunnan, China.
Study design
Cross-sectional survey using partial pol gene sequences collected in 2021, with drug-resistance analysis and molecular network construction.
Population and setting
HIV-1 sequences from Pu'er Prefecture in southwest Yunnan Province, China, a border region adjoining Myanmar, Laos, and Vietnam.
Main findings
Among 295 sequences, CRF08_BC was the most common subtype. Drug-resistance mutations were found in 42.4%, and pretreatment resistance to any antiretroviral class was 10.8%, with NNRTI resistance at 9.5%; resistance was reported as more likely in CRF01_AE. The network analysis identified transregional links, links associated with Lancang County, shared drug-resistance mutations in clusters, and some drug-resistance strains within the network.
Public-health relevance
The authors frame pretreatment resistance, especially NNRTI resistance, as relevant to antiretroviral treatment planning and ongoing surveillance in this border prefecture. The article is also indexed under surveillance, transmission dynamics, and treatment topics, which supports its public-health and epidemiologic context.
Important limitations
The abstract does not state explicit limitations. The evidence here is limited to a single cross-sectional study abstract and metadata, so interpretation requires the full paper for decision-grade detail; the design also does not support temporal inference.
GIDS interpretation
This article is discoverable as a peer-reviewed HIV-1 resistance study with surveillance and transmission-dynamics indexing in a border-region setting. That context supports topical relevance, but the supplied abstract alone does not establish any live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.