Case Report: STAT3 hyper-IgE syndrome in children: two cases report with uncommon complications of tuberculosis and lymphoma
Frontiers in Pediatrics·
- DOI
- 10.3389/fped.2026.1872306
- PMID
- —
- PMCID
- —
- OpenAlex
- W7203754292
- Study type
- Journal article
- Publisher
- Frontiers Media SA
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The report emphasizes the importance of early diagnosis, individualized treatment, and regular follow-up for patients with hyper-IgE syndrome given their susceptibility to severe infections and lymphoma.
Structured evidence summary
Research question
This case report describes the clinical manifestations, treatment outcomes, and prognosis of STAT3 hyper-IgE syndrome in two pediatric patients who developed unusual infectious and malignant complications.
Study design
This is a case report presenting two pediatric cases with detailed clinical descriptions of disease course and treatment outcomes.
Population and setting
Two children diagnosed with STAT3 hyper-IgE syndrome were followed at a single clinical center: a 3-year-old who presented with intestinal intussusception, and a 16-year-old who was diagnosed with lymphoma at age 10.
Main findings
The first patient had probable intestinal tuberculosis with miliary pulmonary tuberculosis that resolved after one year of anti-infection treatment. The second patient developed anaplastic lymphoma kinase-negative anaplastic large cell lymphoma, underwent hematopoietic stem cell transplantation, and died of lung infection three months post-transplant. Both cases illustrate uncommon complications of tuberculosis and lymphoma in STAT3-HIES.
Public-health relevance
The report emphasizes the importance of early diagnosis, individualized treatment, and regular follow-up for patients with hyper-IgE syndrome given their susceptibility to severe infections and lymphoma.
Important limitations
This summary is limited to the supplied single-article abstract and metadata; the original full text is required for decision-grade interpretation. The case report methodology limits generalizability, and the report describes only two patients without comparison to a larger cohort.
GIDS interpretation
This case report describes rare complications of tuberculosis and lymphoma in two children with STAT3 hyper-IgE syndrome. The documented infectious and malignant outcomes provide clinical context regarding disease manifestations in this primary immunodeficiency. The report does not establish surveillance criteria or connect these cases to a signal under active investigation.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.