Hepatic Artery Doppler Haemodynamic Indices as Imaging Biomarkers of Disease Activity in Adults with Chronic Hepatitis B: Correlation with Viral Load and Serum Alanine Transaminase
Nigerian Postgraduate Medical Journal·
- DOI
- 10.4103/npmj.npmj_141_26
- PMID
- —
- PMCID
- —
- OpenAlex
- W7203571493
- Study type
- Cross-sectional study
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings support further consideration of hepatic artery Doppler measurements as non-invasive markers of hepatic vascular changes or disease-related laboratory abnormalities in asymptomatic adults with chronic hepatitis B. The supplied article does not establish effects on patient outcomes, transmission, or population-level disease control.
Structured evidence summary
Research question
The study examined whether hepatic artery Doppler measurements were related to ALT levels and HBV DNA concentrations in adults with hepatitis B, compared with healthy controls.
Study design
This was a comparative cross-sectional study using liver ultrasound, hepatic artery Doppler indices, ALT, and HBV DNA measurements. It included a hepatitis B-positive group and matched healthy controls.
Population and setting
Participants were 143 asymptomatic adults with chronic hepatitis B and 143 matched healthy controls. The supplied abstract does not specify the recruitment setting or geographic location.
Main findings
Hepatic artery resistive and pulsatility indices were higher in the chronic hepatitis B group than in controls, while liver size and echogenicity did not differ significantly. The Doppler indices showed statistically significant correlations with ALT and HBV DNA levels; the abstract also reports that raised ALT and detectable viral load were more frequent among patients receiving treatment.
Public-health relevance
The findings support further consideration of hepatic artery Doppler measurements as non-invasive markers of hepatic vascular changes or disease-related laboratory abnormalities in asymptomatic adults with chronic hepatitis B. The supplied article does not establish effects on patient outcomes, transmission, or population-level disease control.
Important limitations
The cross-sectional design describes associations and does not establish temporal sequence or causality. This summary is limited to the supplied single-article abstract and metadata; the original paper is required for decision-grade assessment of participant selection, measurement methods, treatment-related comparisons, confounding, and statistical results.
GIDS interpretation
The article is discoverable as evidence concerning chronic hepatitis B, Doppler imaging, ALT, and HBV DNA relationships. It provides study-specific clinical context only and does not confirm or characterize a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 7 auditable classifier relationships to diseases, places, topics, and study design.