CPE surveillance is a source-reported epidemiological category focused on Enterobacteriaceae that produce carbapenemase enzymes—β-lactamases capable of hydrolyzing carbapenem antibiotics. Under the Ambler classification, the relevant carbapenemases belong to Class A (KPC), Class B metallo-β-lactamases such as NDM, and Class D (OXA-48-like enzymes) [1]. This surveillance category is narrower than general CRE or CPO concepts and emphasizes genotypic or phenotypic confirmation of carbapenemase production.
Disease overview
BacterialCarbapenemase-producing Enterobacteriaceae surveillance
产碳青霉烯酶肠杆菌科细菌监测
Evidence-backed informationEN 1/6 applicable sections · ZH 1/6 applicable sectionsUpdated Sep 3, 2026
Carbapenemase-producing Enterobacteriaceae (CPE) surveillance tracks Enterobacteriaceae isolates that harbor carbapenemase enzymes conferring carbapenem resistance, a designation distinct from broader carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing organisms (CPO) categories. CPE are recognized as an important and increasing threat to global health, driven by both clonal spread and plasmid-mediated transmission [1]. The carbapenemases detected in CPE fall within three Ambler classes: Class A (e.g., KPC), Class B metallo-β-lactamases (e.g., NDM), and Class D (OXA-48-like) [1].
Read the full clinical and epidemiological profile2
- 1van Duin D et al. The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence. 2017 May 19. PMID: 27593176. doi: 10.1080/21505594.2016.1222343.PubMed: https://pubmed.ncbi.nlm.nih.gov/27593176/
Data access
Page dataset index with source links and update metadata.
Official sourcesAuthority, cadence, notes1
Public Health Ontario IDTO Monthly
Ontario, Canada
Ontario-level current-year preliminary monthly case counts from Public Health Ontario's IDTO report.