This is a broad, non-additive classification scope covering reported CPO detections, explicitly not asserting infection rather than colonization and not synonymous with all CRE [1]. CPO are Gram-negative organisms capable of producing carbapenemase enzymes, detected through phenotypic assays such as growth-based, hydrolysis, or immunoassay methods [2].
Disease overview
Bacterial Evidence-backed information EN 1/6 applicable sections · ZH 1/6 applicable sections Updated Oct 23, 2026
Carbapenemase-producing organisms surveillance refers to a source-reported detection category for CPO that does not distinguish infection from colonization and is not equivalent to all carbapenem-resistant Enterobacteriaceae [1]. The increasing prevalence of CPO is a major global health concern due to the rapid dissemination of mobile genetic elements carrying carbapenemase genes and the limited therapeutic options for associated infections [2].
Read the full clinical and epidemiological profile 2
- 1 GlobalID Disease Ontology. GlobalID ontology concept D133: Carbapenemase-producing organisms surveillance [Internet]. cited 23 Oct 2026. Available from: https://github.com/xmusphlkg/globalID2/blob/development/configs/disease_ontology.json
- 2 Tamma PD et al. Phenotypic Detection of Carbapenemase-Producing Organisms from Clinical Isolates. J Clin Microbiol. 2018 Nov. PMID: 30158194. doi: 10.1128/JCM.01140-18. PubMed: https://pubmed.ncbi.nlm.nih.gov/30158194/
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