Primary infection with a Brazilian chikungunya virus isolate protects immunocompetent mice against detectable viremia following homologous rechallenge
Archives of Virology·
- DOI
- 10.1007/s00705-026-06724-z
- PMID
- —
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The established murine model recapitulates key features of CHIKV infection and provides a platform for investigating viral pathogenesis and evaluating novel antiviral strategies and vaccine candidates.
Structured evidence summary
Research question
The study aimed to establish an experimental model of CHIKV infection in immunocompetent C57BL/6 mice to support development of therapeutic and preventive strategies, including antiviral agents and vaccines.
Study design
An experimental animal study was conducted using immunocompetent C57BL/6 mice infected with a Brazilian CHIKV isolate. Animals were monitored for clinical signs, viremia, viral tissue dissemination, leukocyte counts, and susceptibility to reinfection.
Population and setting
Immunocompetent C57BL/6 mice were infected with a Brazilian CHIKV isolate and monitored over an experimental period.
Main findings
Infected mice exhibited significant viremia and detectable viral loads in popliteal lymph node, femoral bone marrow, and muscle, demonstrating disseminated infection. A global reduction in leukocyte counts was observed. Notably, previously infected mice were resistant to reinfection, indicating protective immunity mediated by neutralizing antibodies. No deaths occurred during the study period.
Public-health relevance
The established murine model recapitulates key features of CHIKV infection and provides a platform for investigating viral pathogenesis and evaluating novel antiviral strategies and vaccine candidates.
Important limitations
This summary is limited to the supplied single-article abstract and metadata; full interpretation requires access to the original paper. The study used an animal model, and translational relevance to human CHIKV infection requires further investigation.
GIDS interpretation
This article contributes foundational preclinical evidence regarding CHIKV pathogenesis and protective immunity in a controlled experimental model. The study was published in Archives of Virology and addresses topics relevant to treatment and vaccination strategies.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.