Pathogenesis and genetic characteristics of novel reassortant low-pathogenic avian influenza H7 viruses isolated from migratory birds in the Republic of Korea in the winter of 2016–2017
Emerging Microbes & Infections·
- DOI
- 10.1038/s41426-018-0181-3
- PMID
- 30442892
- PMCID
- PMC6237977
- OpenAlex
- W2901472224
- Study type
- Genomic study
- Publisher
- Informa UK Limited
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The observed subclinical replication patterns indicate a theoretical risk for undetected poultry dissemination, supporting recommendations for expanded regional monitoring programs across Eurasia.
Structured evidence summary
Research question
This investigation aimed to characterize the genetic composition and biological behavior of newly emerging reassortant low-pathogenicity H7 influenza A viruses circulating among migratory birds in South Korea.
Study design
The research utilized a genomic surveillance framework alongside controlled laboratory infection assays in specific-pathogen-free chickens to evaluate viral replication and transmission dynamics.
Population and setting
Field isolates were collected from wild bird environments across South Korea between 2010 and early 2017, while experimental transmission studies were conducted using specific-pathogen-free chickens.
Main findings
National monitoring revealed a substantial spike in H7 virus detections during early 2017, with phylogenetic mapping placing recent isolates within an Eurasian lineage cluster. Experimental testing demonstrated that a predominant viral genotype achieved rapid systemic multiplication and effective asymptomatic spread among infected chickens.
Public-health relevance
The observed subclinical replication patterns indicate a theoretical risk for undetected poultry dissemination, supporting recommendations for expanded regional monitoring programs across Eurasia.
Important limitations
The summary is restricted to the supplied single-article abstract and metadata, requiring access to the complete manuscript for comprehensive methodological evaluation and decision-grade interpretation.
GIDS interpretation
This publication provides foundational genomic and pathogenicity data relevant to influenza surveillance frameworks, offering contextual insights into viral evolution and host adaptation without indicating any active epidemiological alerts.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.