Phylogenetic and phylogeographic analysis of equine influenza in Colombia.
Equine veterinary journal·
- DOI
- 10.1002/evj.70314
- PMID
- 42644280
- PMCID
- —
- OpenAlex
- —
- Study type
- Genomic study
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The genetic proximity to foreign viral strains highlights cross-border animal trade as a potential introduction pathway, emphasizing the need for continuous genomic monitoring to track strain evolution and guide control measures.
Structured evidence summary
Research question
What were the genetic origins and evolutionary timeline of equine influenza virus strains circulating in Colombian competition horses during the 2020–2023 period?
Study design
The investigation utilized a molecular epidemiological framework, employing whole-genome sequencing and time-scaled phylogenetic modeling to evaluate viral evolution.
Population and setting
Clinical samples were gathered from competition horses exhibiting respiratory illness across two distinct Colombian regions.
Main findings
Sequenced isolates demonstrated high genetic similarity to recent North American H3N8 lineages, with a most recent common ancestor dated to approximately 2020. Researchers also documented multiple amino acid changes, particularly within surface glycoprotein genes, alongside several previously unreported mutations.
Public-health relevance
The genetic proximity to foreign viral strains highlights cross-border animal trade as a potential introduction pathway, emphasizing the need for continuous genomic monitoring to track strain evolution and guide control measures.
Important limitations
The authors note that analyzing only two full genomes constrains broader assessments of regional viral diversity and spread patterns. This summary is restricted to the provided abstract and metadata, necessitating the full manuscript for comprehensive evaluation.
GIDS interpretation
This publication establishes baseline genomic data for regional equine influenza circulation, serving as a reference point for future comparative sequence databases and targeted outbreak investigations.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.