APOBEC3-driven attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor
Nature Communications·
- DOI
- 10.1038/s41467-026-76580-7
- PMID
- —
- PMCID
- —
- OpenAlex
- W7202172697
- Study type
- Journal article
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The article is relevant to monkeypox outbreak investigation and transmission dynamics because it addresses phenotypic differences in a virus lineage associated with the 2022 global epidemic. Its focus on zoonotic MPXV and orthopoxvirus transmission gives it One Health relevance.
Structured evidence summary
Research question
The article examines how the 2022 global outbreak monkeypox virus lineage B.1 differs phenotypically from a closely related earlier clade IIb lineage A.1 virus, with attention to APOBEC3-associated mutations.
Study design
The abstract describes a comparative laboratory study using viral replication and spread assays, innate immune response analyses, mutation mapping, and a mouse model of monkeypox virus infection.
Population and setting
The setting includes clade IIb monkeypox virus lineages associated with West Africa and the 2022 global outbreak, plus experimental cell culture and mouse infection model systems. No human participant population is described in the abstract.
Main findings
The abstract reports that lineage B.1 and A.1 showed similar replication in cell culture, while B.1 had impaired longer-distance spread linked to an APOBEC3-associated change in OPG057. It also reports altered innate immune control linked to an OPG047 change and lower virulence in a mouse model compared with A.1.
Public-health relevance
The article is relevant to monkeypox outbreak investigation and transmission dynamics because it addresses phenotypic differences in a virus lineage associated with the 2022 global epidemic. Its focus on zoonotic MPXV and orthopoxvirus transmission gives it One Health relevance.
Important limitations
The abstract indicates reliance on cell culture experiments and a mouse infection model, so direct interpretation for human disease severity or transmission is limited from the supplied summary alone. This evidence summary is limited to the supplied single-article abstract and metadata and requires the original paper for decision-grade interpretation.
GIDS interpretation
The classifier links make this article discoverable under monkeypox, smallpox, One Health, outbreak investigation, and transmission dynamics. These links provide indexing context only and do not establish any connection to a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.