Dual-route H5N1 vaccination induces systemic and mucosal immunity in murine and bovine models
npj Vaccines·
- DOI
- 10.1038/s41541-026-01460-6
- PMID
- 42014782
- PMCID
- PMC13284322
- OpenAlex
- W4414402707
- Study type
- Genomic study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Publication version
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Open linked preprint →Why this research matters now
The investigation addresses agricultural economic concerns and zoonotic transmission potential by evaluating livestock-targeted immunization strategies against expanding avian influenza lineages.
Structured evidence summary
Research question
How effectively does a dual-administration H5N1 vaccine regimen generate protective immune responses in murine and bovine subjects?
Study design
Controlled preclinical experiment utilizing prime-boost immunization followed by pathogen challenge in laboratory mice and calves.
Population and setting
Murine and bovine animal models maintained under controlled experimental conditions.
Main findings
The immunization protocol stimulated robust humoral and cellular responses across both species. Challenged mice demonstrated complete survival against lethal exposure to divergent H5N1 isolates, including a recently identified bovine strain. Immune profiles remained comparable between animals, indicating potential cross-species relevance.
Public-health relevance
The investigation addresses agricultural economic concerns and zoonotic transmission potential by evaluating livestock-targeted immunization strategies against expanding avian influenza lineages.
Important limitations
Outcomes are confined to controlled animal experiments, preventing direct assessment of efficacy in natural herd settings or human populations.
GIDS interpretation
This publication contributes to the broader literature on avian influenza genomics and veterinary vaccine development. It provides preclinical context for immunogen selection and delivery methods without reflecting real-time outbreak monitoring or active surveillance activity.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 13 auditable classifier relationships to diseases, places, topics, and study design.