Norovirus inter-species transmission in an ex vivo model is dependent on virus internalization capacity
Emerging Microbes & Infections·
- DOI
- 10.1080/22221751.2026.2713851
- PMID
- 42546135
- PMCID
- —
- OpenAlex
- W7172272484
- Study type
- Journal article
- Publisher
- Informa UK Limited
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Clarifying tissue compatibility between human and domestic animal viruses aids One Health frameworks in mapping potential zoonotic interfaces and guiding cross-sectoral monitoring priorities.
Structured evidence summary
Research question
The investigation evaluates whether noroviruses can breach species boundaries by assessing viral attachment and cellular entry across intestinal tissues from multiple animal hosts.
Study design
Authors conducted an ex vivo experiment utilizing precision-cut intestinal slices obtained from swine, canines, and poultry.
Population and setting
The research relies exclusively on isolated tissue models rather than living clinical cohorts or field-based animal populations.
Main findings
Human norovirus particles effectively bound to and entered pig and dog intestinal tissue at levels matching native animal strains, with successful replication observed in porcine samples. Chicken tissue exhibited zero viral interaction, while animal noroviruses showed minimal cellular penetration in human tissue. These patterns suggest that efficient viral uptake acts as a biological filter, making human-to-domestic animal spread more feasible than the opposite direction.
Public-health relevance
Clarifying tissue compatibility between human and domestic animal viruses aids One Health frameworks in mapping potential zoonotic interfaces and guiding cross-sectoral monitoring priorities.
Important limitations
Utilizing isolated intestinal slices prevents evaluation of systemic immune defenses and whole-organism physiological variables that would shape actual infection trajectories.
GIDS interpretation
The manuscript supplies mechanistic data on host-range constraints that could help researchers prioritize viral candidates for future genomic screening efforts within integrated health observation networks.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.