Influenza Vaccine Effectiveness During the 2023/2024 Season: A Test‐Negative Case–Control Study Among Emergency Hospital Admissions With Respiratory Conditions in Northern Ireland
Influenza and Other Respiratory Viruses·
- DOI
- 10.1111/irv.70149
- PMID
- —
- PMCID
- —
- OpenAlex
- W4414111109
- Study type
- Journal article
- Publisher
- Wiley
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The data suggest that routine immunization programs help mitigate the volume of severe respiratory cases necessitating acute hospitalization across multiple age demographics.
Structured evidence summary
Research question
What is the protective capacity of seasonal influenza immunization against laboratory-confirmed respiratory infections requiring emergency hospital care in Northern Ireland during the 2023/2024 season?
Study design
Researchers applied a test-negative case-control framework to contrast vaccination status between laboratory-positive and laboratory-negative patients, incorporating adjustments for confounding factors.
Population and setting
The sample consisted of 2,368 individuals seeking emergency hospital admission for respiratory complaints within Northern Ireland throughout the designated influenza period.
Main findings
Immunization yielded an overall effectiveness estimate of 47.5 percent against confirmed influenza, with substantially greater protection recorded for children aged two to seventeen compared to older adult cohorts. Efficacy metrics fluctuated across viral subtypes and showed a measurable decline when the interval since administration exceeded two months.
Public-health relevance
The data suggest that routine immunization programs help mitigate the volume of severe respiratory cases necessitating acute hospitalization across multiple age demographics.
Important limitations
This summary depends entirely on the provided abstract and bibliographic metadata, requiring examination of the complete original manuscript for thorough methodological assessment and decision-grade interpretation.
GIDS interpretation
The article provides regional context on immunization performance and can be cataloged under influenza prevention and vaccine impact categories for future literature mapping.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.