Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006–2015)
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-025-11913-3
- PMID
- 41249964
- PMCID
- PMC12625239
- OpenAlex
- W4416292014
- Study type
- Genomic study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Publication version
This article has a linked preprint
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Open linked preprint →Why this research matters now
The findings provide genomic context for XDR-TB resistance-associated variation in the studied Argentine isolates. The authors state that the results support continued research and surveillance efforts, but the abstract does not quantify population-level effects or clinical outcomes.
Structured evidence summary
Research question
The study examined the genomic characteristics and resistance-associated variants of XDR Mycobacterium tuberculosis isolates collected in Argentina from 2006 to 2015, including their local and global phylogenetic relationships.
Study design
This was a genomic study using whole-genome sequencing of XDR-TB isolates. Isolate variants were compared with resistance-associated variant databases and analyzed through local and global phylogenetic methods.
Population and setting
The analysis covered XDR Mycobacterium tuberculosis isolates collected in Argentina between 2006 and 2015. The abstract does not report the number of isolates or additional participant characteristics.
Main findings
The frequently observed resistance mutations did not share a common origin. The abstract identifies katG Ser315Thr and fabG1 -15C among notable variants associated with resistance to first-line drugs and describes genetic diversity among resistance-associated variants.
Public-health relevance
The findings provide genomic context for XDR-TB resistance-associated variation in the studied Argentine isolates. The authors state that the results support continued research and surveillance efforts, but the abstract does not quantify population-level effects or clinical outcomes.
Important limitations
The supplied summary is limited to the single-article abstract and bibliographic metadata; the abstract does not provide enough information to assess sampling completeness, isolate representativeness, analytical details, or clinical outcomes. The original paper is required for decision-grade interpretation.
GIDS interpretation
This article is discoverable as an Argentina-focused genomic epidemiology and antimicrobial-resistance study of XDR tuberculosis from 2006–2015. Its findings provide historical study context only and do not confirm or characterize a current live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.