Listeria monocytogenes of two sequence types in a maternal-fetal listeriosis: clinical management and bacterial genomics
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-026-12594-2
- PMID
- 41566238
- PMCID
- PMC12905962
- OpenAlex
- W7125420371
- Study type
- Genomic study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Recognizing atypical disease trajectories and mixed-strain infections emphasizes the value of combining routine clinical evaluation with advanced molecular typing. Routine adoption of genomic sequencing could strengthen diagnostic precision and assist broader monitoring frameworks for perinatal pathogens.
Structured evidence summary
Research question
What clinical and genomic characteristics define a rare dual-strain maternal-fetal listeriosis event?
Study design
The investigation employed a retrospective case analysis integrating clinical chart review with whole-genome sequencing and phylogenetic mapping of bacterial isolates.
Population and setting
The analysis focused on a single pregnant individual and her newborn infant managed within a Chinese clinical environment.
Main findings
Maternal placental inflammation progressed to neonatal congenital infection and respiratory complications, resolving completely after targeted antibiotic administration. Molecular profiling identified a simultaneous infection with two distinct bacterial lineages, one shared between mother and infant and another isolated exclusively from maternal blood, with the latter containing a unique virulence marker while both maintained identical antibiotic susceptibility patterns.
Public-health relevance
Recognizing atypical disease trajectories and mixed-strain infections emphasizes the value of combining routine clinical evaluation with advanced molecular typing. Routine adoption of genomic sequencing could strengthen diagnostic precision and assist broader monitoring frameworks for perinatal pathogens.
Important limitations
The examination relies entirely on a single patient-infant dyad, which restricts statistical power and prevents broad epidemiological extrapolation.
GIDS interpretation
This report supplies a detailed molecular and clinical reference for a rare co-infection scenario, offering baseline data that may support future comparative assessments or database enrichment. Its archival value lies in documenting strain diversity and diagnostic integration rather than signaling an emerging transmission pattern.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.