Seroprevalence, associated factors, and molecular detection of hepatitis B virus co-infection among HIV-positive adults in Okene, Nigeria
Dietary Supplements and Nutraceuticals·
- DOI
- 10.31989/dsn.v5i8.2066
- PMID
- —
- PMCID
- —
- OpenAlex
- —
- Study type
- Cross-sectional study
- Publisher
- Functional Food Center
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The measured infection frequency indicates a persistent dual-viral burden within this regional healthcare setting, reinforcing the value of systematic diagnostic protocols and immunization initiatives.
Structured evidence summary
Research question
This investigation sought to quantify hepatitis B surface antigen positivity and confirm viral presence via genetic testing among a cohort of HIV-diagnosed adults, while evaluating potential demographic and behavioral correlates.
Study design
A hospital-based cross-sectional assessment utilizing rapid antigen screening followed by targeted polymerase chain reaction verification for a subset of participants.
Population and setting
Ninety consenting adult individuals living with HIV who presented to a designated reference facility in Okene, Kogi State, Nigeria.
Main findings
Serological screening detected hepatitis B surface antigen in seven point eight percent of the cohort. Genetic amplification succeeded in sixty percent of the processed molecular subset. Statistical modeling found no significant relationships between infection markers and gender, socioeconomic indicators, or documented exposure histories.
Public-health relevance
The measured infection frequency indicates a persistent dual-viral burden within this regional healthcare setting, reinforcing the value of systematic diagnostic protocols and immunization initiatives.
Important limitations
The observational cross-sectional framework prevents determination of temporal sequences between exposures and infection status. Limited subgroup sizes required exact statistical approaches and constrained the ability to identify meaningful demographic or behavioral patterns.
GIDS interpretation
This report supplies localized epidemiological and genetic data that may assist regional tracking frameworks for overlapping viral conditions. The combined serological and molecular methodology provides a structural reference for subsequent observational investigations.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.