Use of Whole-Genome Sequencing to Link Burkholderia pseudomallei from Air Sampling to Mediastinal Melioidosis, Australia
Emerging Infectious Diseases·
- DOI
- 10.3201/eid2111.141802
- PMID
- 26488732
- PMCID
- PMC4622230
- OpenAlex
- W2411950235
- Study type
- Genomic study
- Publisher
- Centers for Disease Control and Prevention (CDC)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The report is relevant to transmission investigations for melioidosis because it describes environmental sampling paired with genomic comparison in a suspected inhalational case. It may help contextualize how environmental sources are studied in relation to human infection, without establishing broader frequency or surveillance patterns.
Structured evidence summary
Research question
To assess whether air sampling and whole-genome sequencing could connect environmental Burkholderia pseudomallei with the strain recovered from a patient with presumed inhalational melioidosis.
Study design
A genomic study using environmental air sampling and whole-genome sequencing comparison between an environmental isolate and a patient isolate.
Population and setting
A patient residence in Australia, where air samples were collected in relation to a case of mediastinal melioidosis.
Main findings
B. pseudomallei was recovered from air samples at the patient's residence. Whole-genome sequencing showed that the environmental isolate matched the B. pseudomallei recovered from the patient.
Public-health relevance
The report is relevant to transmission investigations for melioidosis because it describes environmental sampling paired with genomic comparison in a suspected inhalational case. It may help contextualize how environmental sources are studied in relation to human infection, without establishing broader frequency or surveillance patterns.
Important limitations
No study limitations are stated in the supplied abstract. This summary is limited to the single provided abstract and metadata; the original paper is needed for decision-grade interpretation.
GIDS interpretation
This article is discoverable within genomic epidemiology and transmission-dynamics literature on melioidosis in Australia. It should be treated as a single-case environmental genomics report rather than evidence of a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.