Case Report: A case of secondary syphilis with clinical manifestations resembling granuloma annulare
Frontiers in Medicine·
- DOI
- 10.3389/fmed.2026.1899418
- PMID
- —
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Frontiers Media SA
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The report underscores the rising incidence of syphilis and the need to recognize atypical clinicopathological presentations, supporting routine syphilis screening for accurate diagnosis and timely treatment.
Structured evidence summary
Research question
The case report describes an atypical presentation of secondary syphilis mimicking granuloma annulare, emphasizing diagnostic and management considerations.
Study design
Single-patient case report, peer-reviewed journal article.
Population and setting
A single patient presenting with diffuse granuloma annulare–like lesions across the neck, chest, abdomen, back, and upper extremities, evaluated in a clinical care setting.
Main findings
Diagnosis of secondary syphilis was confirmed by skin biopsy and serology. The patient responded well to penicillin treatment, with a non-treponemal test (TRUST) becoming negative 7 months after therapy.
Public-health relevance
The report underscores the rising incidence of syphilis and the need to recognize atypical clinicopathological presentations, supporting routine syphilis screening for accurate diagnosis and timely treatment.
Important limitations
The summary is limited to the supplied single-article abstract and metadata; no explicit limitations are stated in the abstract, and the original paper is required for decision-grade interpretation.
GIDS interpretation
The article is discoverable through disease and topic classifiers for syphilis and treatment; it provides contextual clinical information and does not constitute a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 5 auditable classifier relationships to diseases, places, topics, and study design.