Strengthening the influenza vaccine virus selection and development process
Vaccine·
- DOI
- 10.1016/j.vaccine.2015.06.090
- PMID
- 26148877
- PMCID
- —
- OpenAlex
- W793806714
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The abstract frames influenza vaccines as central to public health preparedness for seasonal and potentially pandemic influenza, and highlights equitable access to effective and affordable vaccines as a growing global demand.
Structured evidence summary
Research question
The article addresses how to strengthen the processes used to select and develop influenza vaccine viruses, including surveillance inputs, laboratory assays, and emerging technologies.
Study design
The bibliographic metadata describes a peer-reviewed journal article; the abstract reads as a narrative review covering multiple thematic areas of the vaccine virus selection and development pipeline rather than reporting a primary empirical study.
Population and setting
The discussion is framed globally, referencing WHO GISRS, national surveillance systems, manufacturers, regulatory authorities, and both temperate and tropical regions; no specific study population or country setting is defined.
Main findings
The abstract states that coordinated virological and epidemiological surveillance underpins vaccine virus selection, that sustaining recent surveillance gains is a challenge, and that improvements are needed in the timeliness and representativeness of shared viruses and in understanding transmission seasonality, especially in tropical regions. It also notes ongoing limitations of HAI assays, the potential of next-generation sequencing and other high-throughput tools, and that egg-based inactivated and live attenuated vaccines continue to dominate the vaccine landscape.
Public-health relevance
The abstract frames influenza vaccines as central to public health preparedness for seasonal and potentially pandemic influenza, and highlights equitable access to effective and affordable vaccines as a growing global demand.
Important limitations
The abstract itself does not enumerate explicit study limitations; this summary is therefore restricted to the supplied single-article abstract and metadata and would require the original full paper for any decision-grade interpretation.
GIDS interpretation
For the GIDS context, the article is relevant as background literature on influenza surveillance, vaccine virus selection, and transmission dynamics, including H5N1 per the disease classifier, and could support discoverability of surveillance-related work; this summary does not link the paper to any live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.