Impact and effectiveness of pentavalent rotavirus vaccine in children <5 years of age in Burkina Faso
Vaccine·
- DOI
- 10.1016/j.vaccine.2017.12.056
- PMID
- 29290478
- PMCID
- PMC9237810
- OpenAlex
- W2778462376
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings document the real-world impact of rotavirus vaccine in one of the first African countries to introduce RV5 nationally, demonstrating reductions in rotavirus-associated hospitalizations and supporting vaccine policy in similar settings.
Structured evidence summary
Research question
The study assessed the impact and effectiveness of pentavalent rotavirus vaccine (RV5) on acute gastroenteritis hospitalizations among children under five years of age in Burkina Faso following vaccine introduction in October 2013.
Study design
Sentinel hospital-based surveillance was conducted at four hospitals from December 2013 through February 2017. Unconditional logistic regression compared vaccination odds among rotavirus-positive cases and rotavirus-negative controls, adjusting for age, season, hospital site, and socioeconomic factors.
Population and setting
The study included children under five years of age hospitalized for acute gastroenteritis at four sentinel hospitals in Burkina Faso. Demographic, clinical, and vaccination data were collected, and stool specimens were tested by enzyme immunoassay.
Main findings
The proportion of acute gastroenteritis hospitalizations testing positive for rotavirus declined significantly among children under five, particularly among infants. RV5 provided significant protection against severe rotavirus gastroenteritis in infants, though effectiveness decreased in older children.
Public-health relevance
The findings document the real-world impact of rotavirus vaccine in one of the first African countries to introduce RV5 nationally, demonstrating reductions in rotavirus-associated hospitalizations and supporting vaccine policy in similar settings.
Important limitations
This summary relies on the supplied single-article abstract and bibliographic metadata. Full interpretation of study limitations, including potential selection bias from sentinel surveillance, confounding, and generalizability, requires review of the complete published article.
GIDS interpretation
The article was classified under gastroenteritis surveillance and vaccine effectiveness topics in Burkina Faso. This classification supports literature discoverability for rotavirus vaccine program evaluation but does not constitute detection of a live public health signal or outbreak event.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.