Effectiveness of Monovalent Rotavirus Vaccine Against Hospitalization With Acute Rotavirus Gastroenteritis in Kenyan Children
Clinical Infectious Diseases·
- DOI
- 10.1093/cid/ciz664
- PMID
- 31326980
- PMCID
- PMC7245145
- OpenAlex
- W2963382129
- Study type
- Journal article
- Publisher
- Oxford University Press (OUP)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Findings support the protective benefit of RV1 within the Kenyan immunization program and indicate that efforts to improve vaccine uptake and nutritional status may be important to maximize impact.
Structured evidence summary
Research question
The study assessed monovalent rotavirus vaccine (RV1) effectiveness against rotavirus-associated hospitalization among Kenyan children following vaccine introduction.
Study design
Multi-site hospital-based surveillance using a case-control design (rotavirus-positive cases vs. rotavirus-negative controls) with multivariable logistic regression to derive vaccine effectiveness from adjusted odds ratios.
Population and setting
Children age-eligible for at least one RV1 dose, enrolled between July 2014 and December 2017 at three Kenyan hospitals under acute gastroenteritis surveillance.
Main findings
Among 677 eligible children, 110 (16%) were rotavirus positive. Overall two-dose RV1 effectiveness against rotavirus-associated hospitalization was 64% (95% CI, 35%–80%), and the abstract reports that effectiveness persisted beyond infancy, though the age-specific estimate is truncated. The authors note that malnutrition appears to diminish vaccine effectiveness.
Public-health relevance
Findings support the protective benefit of RV1 within the Kenyan immunization program and indicate that efforts to improve vaccine uptake and nutritional status may be important to maximize impact.
Important limitations
The abstract does not enumerate explicit study limitations. This summary is limited to the supplied single-article abstract/metadata and requires the original paper for decision-grade interpretation.
GIDS interpretation
Classified under gastroenteritis surveillance, vaccination, and vaccine effectiveness for Kenya. This study could contribute to contextual evidence for rotavirus vaccine performance in sub-Saharan Africa but does not by itself confirm any active surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.