Immune response to influenza and pneumococcal vaccines in adults with inflammatory bowel disease: A systematic review and meta-analysis of 1429 patients
Vaccine·
- DOI
- 10.1016/j.vaccine.2022.02.027
- PMID
- 35227523
- PMCID
- —
- OpenAlex
- W4214754147
- Study type
- Systematic review
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The compiled outcomes highlight that standard respiratory immunizations maintain measurable antibody generation in this demographic, providing epidemiological context for infection mitigation frameworks.
Structured evidence summary
Research question
To assess how effectively influenza and pneumococcal vaccines stimulate protective antibody responses among adults managing inflammatory bowel disease under varying therapeutic regimens.
Study design
A peer-reviewed systematic review and meta-analysis synthesizing data from twelve independent investigations.
Population and setting
Adult individuals diagnosed with inflammatory bowel disease who were undergoing diverse pharmacological management, ranging from standard immunosuppressants to biologic agents.
Main findings
Antibody conversion and protection rates for both targeted vaccines remained statistically similar between conventionally treated patients and those without immunosuppression. Conversely, administration of anti-tumor necrosis factor agents alone or alongside other drugs correlated with markedly diminished pneumococcal seroconversion, whereas influenza protection metrics showed no significant variation across those biologic categories.
Public-health relevance
The compiled outcomes highlight that standard respiratory immunizations maintain measurable antibody generation in this demographic, providing epidemiological context for infection mitigation frameworks.
Important limitations
The current assessment relies exclusively on the provided abstract and bibliographic metadata, omitting granular methodological details. Access to the complete manuscript is necessary to achieve decision-grade interpretation and evaluate underlying study heterogeneity.
GIDS interpretation
This record establishes a baseline reference for vaccine responsiveness in a chronic digestive disorder, offering searchable context for future inquiries into prophylactic efficacy or infection risk stratification within comparable clinical populations.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.