Advances in research and application of therapeutic antibody strategies for porcine rotavirus prevention and control
Vaccine·
- DOI
- 10.1016/j.vaccine.2026.128777
- PMID
- 42247746
- PMCID
- —
- OpenAlex
- W7163679130
- Study type
- Journal article
- Publisher
- Elsevier BV
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The work addresses a pathogen relevant to both livestock production economics and comparative gastroenteritis research, and may inform mucosal antibody-based interventions for neonatal diarrheal disease.
Structured evidence summary
Research question
The review examines how therapeutic antibodies could supplement existing immunoprophylaxis against porcine rotavirus (PoRV), with emphasis on antibody engineering, in vitro reconstruction, and oral delivery platforms.
Study design
Narrative review article synthesizing current knowledge on PoRV immunoprophylaxis limitations and therapeutic antibody strategies; no primary experimental data are presented in the abstract.
Population and setting
The focus is on neonatal piglets affected by acute PoRV enteric infection, with broader context referencing rotavirus as a cause of gastroenteritis in young children and neonatal animals.
Main findings
Current PoRV control relies on vaccination and maternally derived antibodies, but genotype diversity and antigenic drift limit cross-protection. Therapeutic antibodies are proposed as a rapid, specific supplement to maternal immunity, particularly via oral delivery to the intestinal mucosa.
Public-health relevance
The work addresses a pathogen relevant to both livestock production economics and comparative gastroenteritis research, and may inform mucosal antibody-based interventions for neonatal diarrheal disease.
Important limitations
This summary is limited to the supplied single-article abstract and metadata; no explicit limitations are stated in the abstract. The full original paper is required for decision-grade interpretation.
GIDS interpretation
As a review of antibody-based prevention strategies for a non-human pathogen, the article provides contextual scientific background on rotavirus countermeasures rather than actionable surveillance signal detection.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.