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Peer reviewedHistorical baselineZika virus disease

Zika Virus and Birth Defects--Reviewing the Evidence for Causality.

The New England journal of medicine·

Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR

DOI
10.1056/nejmsr1604338
PMID
27074377
PMCID
OpenAlex
Study type
Journal article
Publisher
Publisher unavailable
Article type
journal-article
Integrity
current

Why this research matters now

A key causality review for Zika-associated birth defects and public-health decision making.

01

Structured evidence summary

Research question

How strong was the evidence that Zika virus infection could cause birth defects?

Study design

Causality evidence review.

Population and setting

This field has not yet received a quality-gated evidence summary. Consult the original article.

Main findings

This field has not yet received a quality-gated evidence summary. Consult the original article.

Public-health relevance

Links surveillance signals, pregnancy outcomes, and public-health guidance during the Zika emergency.

Important limitations

Limitations could not be fully assessed from the available metadata.

GIDS interpretation

Use as historical context for congenital-outcome evidence around arboviral threats.

02

Related GIDS surveillance

Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.

03

Evidence relationships

This article has 7 auditable classifier relationships to diseases, places, topics, and study design.

about diseaseaddresses topicaddresses topicaddresses topicevaluates interventioninforms policy domainuses study design