UGT1A1 gene polymorphisms and their impact on plasma trough concentrations of dolutegravir in Chinese adults with human immunodeficiency virus-1 infection.
Chinese medical journal·
- DOI
- 10.1097/cm9.0000000000004204
- PMID
- 42634956
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings identify genetic variants that substantially affect dolutegravir drug levels in Han Chinese populations, which may inform dosing strategies and therapeutic drug monitoring for HIV-1 treatment in this ethnic group.
Structured evidence summary
Research question
The study investigated how polymorphisms in the UGT1A1 gene affect plasma trough concentrations of dolutegravir in Han Chinese adults living with HIV-1.
Study design
Han Chinese adults receiving dolutegravir for at least 10 days were enrolled from a single outpatient clinic between September and November 2024. Seven segments of the UGT1A1 gene were amplified to identify polymorphisms, and associations with dolutegravir plasma trough concentrations were analyzed.
Population and setting
The study enrolled 287 Han Chinese adults with HIV-1 infection from the Outpatient Department of Infection and Immunity at Shanghai Public Health Clinical Center. The population was 96.2% male with a median age of 40 years.
Main findings
The most common UGT1A1 alleles identified were UGT1A1*6 (31.7% heterozygotes, 4.2% homozygotes), UGT1A1*28 (22.0% heterozygotes, 1.4% homozygotes), and UGT1A1*60 (49.1% heterozygotes, 8.0% homozygotes). Patients carrying one or two UGT1A1*6 alleles had significantly higher dolutegravir trough concentrations than those with wild-type genotype. UGT1A1*6 presence, compound heterozygosity of UGT1A1*6/*60 or UGT1A1*6/*28/*60, and low body weight were significant factors contributing to elevated dolutegravir concentrations.
Public-health relevance
The findings identify genetic variants that substantially affect dolutegravir drug levels in Han Chinese populations, which may inform dosing strategies and therapeutic drug monitoring for HIV-1 treatment in this ethnic group.
Important limitations
This summary relies on the supplied single-article abstract and metadata. The study was conducted at a single center over a two-month period with a population that was predominantly male, which may limit generalizability. The full paper is required for decision-grade interpretation of methods, statistical analyses, and clinical implications.
GIDS interpretation
This article was classified under AIDS and Treatment topics, indicating its relevance for infectious disease surveillance systems tracking HIV pharmacogenomics and antiretroviral therapy optimization. The study contributes population-specific pharmacokinetic data that may inform treatment monitoring in Han Chinese populations.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 7 auditable classifier relationships to diseases, places, topics, and study design.