Multicenter Study on Children With Bordetella parapertussis Infections
Pediatric Infectious Disease Journal·
- DOI
- 10.1097/inf.0000000000005383
- PMID
- 42642803
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings provide clinical context for B. parapertussis monoinfection in children, including symptom patterns, hospitalization, and antimicrobial use. The abstract indicates that further research is needed to clarify antibiotic-use indications.
Structured evidence summary
Research question
The study examined the clinical course and management of Bordetella parapertussis infection in children with confirmed monoinfection, including symptoms, hospitalization, and antimicrobial treatment.
Study design
This was a multicenter retrospective study conducted at 10 hospitals from April 2023 through March 2024. Children with B. parapertussis detected by BioFire Respiratory Panel 2.1 were included after cases with coinfections were excluded.
Population and setting
The study included patients aged 15 years or younger who underwent multiplex respiratory PCR testing at 10 hospitals. Of 139 patients with B. parapertussis detected, 29 without coinfection were analyzed; the median age was 3 years.
Main findings
Among the 29 analyzed children, 72.4% were hospitalized and 62.1% received antimicrobial therapy; 55.2% had comorbidities. Cough and fever were common, no inspiratory whoop or cyanosis was reported, and there were no fatalities. The abstract reports more frequent febrile illness than in classical pertussis and notes that some patients recovered without antimicrobial treatment.
Public-health relevance
The findings provide clinical context for B. parapertussis monoinfection in children, including symptom patterns, hospitalization, and antimicrobial use. The abstract indicates that further research is needed to clarify antibiotic-use indications.
Important limitations
The retrospective design, analysis of only 29 monoinfection cases, and exclusion of coinfections limit the scope of the reported findings. This summary relies on the supplied single-article abstract and metadata; the original paper is required for decision-grade interpretation.
GIDS interpretation
The article is discoverable in the supplied classification under Pertussis and Treatment and concerns pediatric B. parapertussis infection. The supplied evidence does not establish or confirm any live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.