Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China
Emerging Microbes & Infections·
- DOI
- 10.1080/22221751.2019.1587315
- PMID
- 30898080
- PMCID
- PMC6455148
- OpenAlex
- W2925222194
- Study type
- Genomic study
- Publisher
- Informa UK Limited
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings describe erythromycin resistance and genomic diversity among the studied Chinese B. pertussis isolates, including resistant lineages and a newly reported fhaB3 allele. The abstract states that continued monitoring in China is needed to better understand pathogen evolution.
Structured evidence summary
Research question
The study examined the genomic origins and phylogenetic relationships of erythromycin-resistant Bordetella pertussis isolates collected in China.
Study design
This was a genomic study of Chinese B. pertussis isolates collected from 2012 to 2015. The isolates underwent erythromycin susceptibility testing and MLVA; 50 isolates were additionally analyzed by whole-genome sequencing and phylogenetic methods.
Population and setting
The study included 167 B. pertussis isolates from China collected between 2012 and 2015. Whole-genome sequencing and phylogenetic analysis were performed on a subset of 50 isolates.
Main findings
All but four isolates were erythromycin-resistant, and three of the four susceptible isolates were non-ptxP1. MLVA types MT55, MT104, and MT195 predominated. Phylogenetic analysis identified three independent erythromycin-resistant lineages, and resistant isolates carried a 23S rRNA mutation; a novel fhaB3 allele was reported uniquely among Chinese ptxP1 isolates.
Public-health relevance
The findings describe erythromycin resistance and genomic diversity among the studied Chinese B. pertussis isolates, including resistant lineages and a newly reported fhaB3 allele. The abstract states that continued monitoring in China is needed to better understand pathogen evolution.
Important limitations
The supplied evidence is limited to one article's abstract and bibliographic metadata. The abstract does not establish how representative the 167 isolates were of B. pertussis in China or provide the original paper's full methods, sampling context, or detailed uncertainty estimates; decision-grade interpretation requires review of the full article.
GIDS interpretation
This article is discoverable as evidence concerning genomic epidemiology, erythromycin resistance, vaccination-related topics, and B. pertussis in China. It provides article-level context only and does not establish or confirm a current surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 11 auditable classifier relationships to diseases, places, topics, and study design.