Updated Assessment of the Impact of the Modified Council of State and Territorial Epidemiologists Case Definition for Pertussis on Reported Pertussis
Clinical Infectious Diseases·
- DOI
- 10.1093/cid/ciag515
- PMID
- 42628970
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Oxford University Press (OUP)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings indicate that changes in the pertussis case definition affect interpretation of reported disease trends over time. The abstract describes the 2020 definition change as contributing to the magnitude of the reported 2024 increase.
Structured evidence summary
Research question
The study assessed how the 2020 CSTE pertussis case-definition change affected the number of cases reported to the NNDSS, including its contribution to the increase observed in 2024.
Study design
The analysis compared EPS cases with cough onset from 2021 through 2024 under the 2014 and 2020 case definitions. It applied the proportion of cases newly reportable under the 2020 definition to NNDSS data to estimate additional captured cases.
Population and setting
The study used U.S. Enhanced Pertussis Surveillance cases from 2021 through 2024 and NNDSS pertussis reporting data, including preliminary 2024 data.
Main findings
The proportion of EPS cases newly reportable under the 2020 definition increased from 8.6% in 2021 to 38.0% in 2024. The abstract estimates that 38.0% of preliminary 2024 NNDSS cases would not have met the 2014 definition, and that the observed 133% increase in reported cases from 2019 to 2024 would have been 44% without the definition change.
Public-health relevance
The findings indicate that changes in the pertussis case definition affect interpretation of reported disease trends over time. The abstract describes the 2020 definition change as contributing to the magnitude of the reported 2024 increase.
Important limitations
The estimates use preliminary 2024 NNDSS data and project an EPS-derived proportion onto NNDSS data. This summary is limited to the supplied single-article abstract and metadata; the original paper is required for decision-grade assessment of methods, uncertainty, and additional limitations.
GIDS interpretation
The article is discoverable as a U.S. pertussis surveillance analysis concerning case-definition effects on reported counts and trend interpretation. It provides context for interpreting reported pertussis data but does not, from the supplied evidence, confirm any live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 7 auditable classifier relationships to diseases, places, topics, and study design.