Hepatitis B in Organ Transplantation-Current Evidence and Clinical Gaps.
Transplant infectious disease : an official journal of the Transplantation Society·
- DOI
- 10.1111/tid.70299
- PMID
- 42644756
- PMCID
- —
- OpenAlex
- —
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
By addressing a viral infection affecting hundreds of millions globally, the review highlights how optimized antiviral protocols and broader donor eligibility can enhance transplant system capacity and patient survival.
Structured evidence summary
Research question
This review examines current evidence and identifies clinical gaps concerning hepatitis B virus management among organ donors and recipients across liver and non-liver transplants.
Study design
The publication is a peer-reviewed narrative review synthesizing existing literature on hepatitis B virus interventions and outcomes in transplantation settings.
Population and setting
The scope encompasses individuals undergoing liver or kidney transplantation, as well as organ donors characterized by either active hepatitis B infection or prior exposure markers.
Main findings
Nucleos(t)ide analogue therapy significantly improves post-transplant survival and reduces liver transplant demand for hepatitis B patients. Recipients with prior exposure achieve favorable outcomes through monitoring or prophylaxis, while donor availability increases when utilizing donors with positive core antibodies or surface antigens.
Public-health relevance
By addressing a viral infection affecting hundreds of millions globally, the review highlights how optimized antiviral protocols and broader donor eligibility can enhance transplant system capacity and patient survival.
Important limitations
This summary relies exclusively on the provided abstract and metadata, requiring access to the full manuscript for comprehensive methodological evaluation and decision-grade interpretation.
GIDS interpretation
The article’s indexing under treatment and vaccination topics, combined with its title, positions it as a reference point for literature searches targeting hepatitis B management frameworks in transplant care.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 7 auditable classifier relationships to diseases, places, topics, and study design.