Global burden and forecast of acute viral hepatitis B among women of childbearing age: a systematic analysis of the global burden of disease study 2021.
BMC infectious diseases·
- DOI
- 10.1186/s12879-026-13302-w
- PMID
- 42143225
- PMCID
- PMC13227652
- OpenAlex
- W7161403056
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
These epidemiological insights assist policymakers in designing region-targeted intervention frameworks and support broader international objectives for viral hepatitis management. The results emphasize the continued importance of sustaining immunization programs, enforcing sterile medical practices, and delivering effective maternal transmission safeguards.
Structured evidence summary
Research question
The investigation examines historical disease metrics and future epidemiological projections for acute hepatitis B within a specific female demographic over three decades.
Study design
Researchers utilized longitudinal data extracted from an international health database, applying statistical regression and Bayesian forecasting techniques to evaluate past patterns and estimate future trajectories.
Population and setting
The analysis concentrates on females of reproductive age across multiple countries, with further categorization based on regional socio-demographic development indices.
Main findings
Worldwide metrics for incidence, prevalence, mortality, and disability-adjusted life years demonstrated consistent reductions between 1990 and 2021. Mid-century projections anticipate continued downward movements across all measured indicators, though mortality and disability reductions are expected to proceed more gradually. Substantially elevated disease loads were identified in regions characterized by lower socio-demographic development.
Public-health relevance
These epidemiological insights assist policymakers in designing region-targeted intervention frameworks and support broader international objectives for viral hepatitis management. The results emphasize the continued importance of sustaining immunization programs, enforcing sterile medical practices, and delivering effective maternal transmission safeguards.
Important limitations
The methodology relies exclusively on aggregated statistical modeling and secondary database records rather than direct clinical observations. Predictive outputs inherently contain mathematical uncertainties, and the analytical framework does not account for individual patient outcomes or localized programmatic implementation challenges.
GIDS interpretation
This work offers a macro-level epidemiological perspective focused on historical quantification and mathematical forecasting for a defined demographic cohort. Its reliance on longitudinal database aggregation makes it suitable for tracking broad temporal shifts and regional inequalities rather than assessing immediate community-level transmission activity.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 14 auditable classifier relationships to diseases, places, topics, and study design.