Receptor profiling and growth assessment of influenza A virus in porcine mammary and non-mammary tissues and derived cells
Journal of Virology·
- DOI
- 10.1128/jvi.00615-26
- PMID
- 42405777
- PMCID
- —
- OpenAlex
- W7167480187
- Study type
- Journal article
- Publisher
- American Society for Microbiology
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Identifying alternative replication niches in livestock anatomy aids in evaluating cross-species transmission risks and monitoring viral adaptation pathways in agricultural environments.
Structured evidence summary
Research question
The investigation seeks to determine whether porcine mammary tissue supports influenza A virus entry and replication compared to respiratory tract tissue.
Study design
This laboratory experiment characterized viral receptor distribution, measured binding affinities, and quantified viral growth across isolated and immortalized epithelial cells from swine mammary and respiratory origins.
Population and setting
Research utilized porcine mammary and respiratory tract samples alongside corresponding primary and immortalized cell cultures.
Main findings
Porcine mammary tissue expresses both SA-α2,3 and SA-α2,6 receptors, enabling variable viral attachment. Bovine H5N1 isolates demonstrate efficient replication in both mammary and respiratory cell lines, while other avian, swine, and human strains exhibit moderate growth in mammary epithelium but robust proliferation in respiratory counterparts. These results indicate that swine mammary tissue functions as a viable environment for viral multiplication and potential genetic reassortment.
Public-health relevance
Identifying alternative replication niches in livestock anatomy aids in evaluating cross-species transmission risks and monitoring viral adaptation pathways in agricultural environments.
Important limitations
The evaluation depends entirely on the provided abstract and bibliographic metadata, requiring access to the complete manuscript for comprehensive methodological verification and decision-grade interpretation. No explicit constraints were detailed within the supplied source material.
GIDS interpretation
This report contributes baseline virological context regarding host tissue compatibility that may guide future investigative priorities within the One Health domain, without implying direct alignment with ongoing epidemiological tracking initiatives.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.