Population-level health and economic impacts of introducing Vaccae vaccination in China: a modelling study
BMJ Global Health·
- DOI
- 10.1136/bmjgh-2023-012306
- PMID
- 37257938
- PMCID
- PMC10254880
- OpenAlex
- —
- Study type
- Mathematical modelling
- Publisher
- BMJ
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The study addresses TB control in the context of population ageing in China and may support evidence-based decisions on TB vaccination strategy and reimbursement.
Structured evidence summary
Research question
The study evaluates the population-level health and economic impacts of introducing the Vaccae TB vaccine in China to inform vaccination policy.
Study design
A modelling study using an age-structured compartmental model, with cost analyses from the healthcare sector perspective discounted at 3%, comparing three vaccination scenarios.
Population and setting
The setting is a national TB vaccination programme in China initiated in 2024, evaluating three strategies: no Vaccae, mass vaccination of people aged 15-74 years, and targeted vaccination of older adults aged 60 years.
Main findings
Targeted vaccination of older adults modestly reduced TB burden (~20%), averting an estimated 8.01 million TB cases and 0.20 million deaths over 2024-2050, with an ICER of US$4,387 per DALY averted and a total budget of about US$22.5 billion. Mass vaccination produced a larger impact on TB incidence but with substantially higher costs. Both preinfection and postinfection efficacy types could yield incidence reductions exceeding 40% in 2050, provided the vaccine price remains ≤US$5 per dose.
Public-health relevance
The study addresses TB control in the context of population ageing in China and may support evidence-based decisions on TB vaccination strategy and reimbursement.
Important limitations
Limitations are not explicitly stated in the supplied abstract. This summary is limited to the supplied single-article abstract/metadata and requires the original paper for decision-grade interpretation.
GIDS interpretation
The article is indexed under tuberculosis, vaccination, health policy, and transmission dynamics, and is discoverable as a modelling-based evaluation of a specific TB vaccine candidate in China. No connection to a live surveillance signal is made.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.