Rapid diagnosis of alveolar echinococcosis from lung puncture sample using metagenomic next-generation sequencing: a case report
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-024-09553-0
- PMID
- 38982338
- PMCID
- PMC11232253
- OpenAlex
- W4400461348
- Study type
- Journal article
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The report is relevant to rare-infection diagnostics and literature discovery for alveolar echinococcosis, especially where routine testing did not identify a cause. It sits within the article's diagnostics and One Health framing.
Structured evidence summary
Research question
To describe whether metagenomic next-generation sequencing of a lung puncture specimen could identify Echinococcus multilocularis and support diagnosis of alveolar echinococcosis in a patient with pulmonary nodules.
Study design
Single-patient case report published as a journal article.
Population and setting
A 45-year-old woman evaluated in a hospital for more than 3 months of pulmonary shadows, with CT showing multiple lung nodules and abdominal CT showing lesions in both liver lobes.
Main findings
The lung puncture tissue mNGS result reported 6,156 reads matching E. multilocularis, and the patient was diagnosed with alveolar echinococcosis. After albendazole treatment, she was described as stable during follow-up.
Public-health relevance
The report is relevant to rare-infection diagnostics and literature discovery for alveolar echinococcosis, especially where routine testing did not identify a cause. It sits within the article's diagnostics and One Health framing.
Important limitations
No explicit study limitations were stated in the abstract. The summary is limited to the supplied single-article abstract and metadata, so full-paper review would be needed for decision-grade interpretation.
GIDS interpretation
This is a single case report that may help discover literature on mNGS-based identification of echinococcosis. It does not support any inference about a broader live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.