Clinical and laboratory characteristics of human brucellosis and predictors of focal involvement: a retrospective cohort study from Türkiye
BMC Infectious Diseases·
- DOI
- 10.1186/s12879-026-13760-2
- PMID
- 42277739
- PMCID
- —
- OpenAlex
- W7164352338
- Study type
- Cohort study
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The authors propose that integrating routine blood tests into initial assessments could streamline diagnostic pathways for suspected complicated infections.
Structured evidence summary
Research question
The investigation sought to determine which clinical and laboratory variables correlate with localized disease manifestations in brucellosis, specifically assessing whether C-reactive protein and neutrophil-to-lymphocyte ratio offer predictive utility.
Study design
Researchers conducted a retrospective observational cohort analysis utilizing medical records from a single hospital.
Population and setting
The sample comprised adults treated for brucellosis at a Turkish tertiary care facility over a five-year period spanning 2021 to 2025.
Main findings
Nearly one-third of the enrolled individuals developed localized complications, predominantly involving the spine and joints. Those with restricted disease presented at an older age and demonstrated markedly elevated inflammatory indices compared to the remainder of the cohort.
Public-health relevance
The authors propose that integrating routine blood tests into initial assessments could streamline diagnostic pathways for suspected complicated infections.
Important limitations
The reliance on historical data from a single center restricts broader applicability, and the authors acknowledge that forward-looking multicenter trials are necessary to verify the results.
GIDS interpretation
This report establishes a baseline understanding of laboratory patterns accompanying complicated brucellosis cases in a defined region. It offers contextual information on potential risk indicators without suggesting active monitoring or confirming current transmission trends.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 9 auditable classifier relationships to diseases, places, topics, and study design.