Field evaluation of SumiLarv™ 2MR larvicide for controlling the invasive malaria vector Anopheles stephensi in Ethiopia: a randomised controlled trial
Malaria Journal·
- DOI
- 10.1186/s12936-026-06089-3
- PMID
- —
- PMCID
- —
- OpenAlex
- W7203653082
- Study type
- Randomised controlled trial
- Publisher
- Springer Science and Business Media LLC
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings suggest SumiLarv 2MR may be a suitable larval source management tool against the invasive urban-tolerant vector An. stephensi, which complicates existing malaria control in Ethiopia.
Structured evidence summary
Research question
The trial evaluated whether SumiLarv 2MR, a pyriproxyfen-based larvicide, can suppress emergence of the invasive malaria vector Anopheles stephensi in large artificial water-storage containers.
Study design
A habitat-randomised controlled trial in which 102 large artificial containers (birkas) were allocated 1:1 to a SumiLarv 2MR treatment arm or an untreated control arm, with biweekly assessment of adult emergence inhibition over 40 weeks.
Population and setting
Birkas (large artificial water-storage containers) in Danan town, Somali region of Ethiopia, where entomological surveillance had identified breeding of An. stephensi.
Main findings
SumiLarv 2MR produced complete (100%) inhibition of adult mosquito emergence throughout the 40-week follow-up (t = 6.26, p < 0.05), with no significant differences in water volume, pH, or temperature between arms. Molecular confirmation indicated that approximately 98.91% of tested specimens were An. stephensi, and post-trial analysis showed about 82.20% of the original pyriproxyfen had been released from the discs.
Public-health relevance
The findings suggest SumiLarv 2MR may be a suitable larval source management tool against the invasive urban-tolerant vector An. stephensi, which complicates existing malaria control in Ethiopia.
Important limitations
No limitations are explicitly stated in the supplied abstract; this summary is limited to the supplied single-article abstract and metadata and requires review of the original paper for decision-grade interpretation.
GIDS interpretation
The study addresses detection, characterisation, and control of an invasive malaria vector in Ethiopia, a topic pertinent to GIDS discoverability; the supplied abstract does not demonstrate linkage of this trial to a live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.