Coverage and Effectiveness of Kyasanur Forest Disease (KFD) Vaccine in Karnataka, South India, 2005–10
PLoS Neglected Tropical Diseases·
- DOI
- 10.1371/journal.pntd.0002025
- PMID
- 23359421
- PMCID
- PMC3554520
- OpenAlex
- W2064153118
- Study type
- Journal article
- Publisher
- Public Library of Science (PLoS)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The findings indicate suboptimal vaccination uptake and reduced vaccine effectiveness in the field setting, underscoring the need to expand coverage and investigate reasons for the diminished protection reported here.
Structured evidence summary
Research question
The study examines vaccine coverage and effectiveness of the Kyasanur Forest Disease (KFD) vaccine in Karnataka, India, during 2005–2010, in light of recent KFD cases observed among vaccinated individuals.
Study design
A retrospective analysis of KFD vaccination records and case surveillance data from 2005 to 2010, with calculation of incidence among vaccinated and unvaccinated groups, relative risk, and vaccine effectiveness.
Population and setting
Residents of five KFD-affected districts in Karnataka state, South India, eligible for vaccination (aged 7–65 years), assessed between 2005 and 2010; 343,256 individuals were eligible, though 2008 vaccination details were unavailable.
Main findings
Vaccine coverage was low: 52% of eligible individuals were unvaccinated and 36% had received two doses plus a booster. Of 168 laboratory-confirmed KFD cases, 80% were unvaccinated. Reported vaccine effectiveness was 62.4% after two doses and 82.9% after two doses plus a booster, lower than in earlier studies, with limited protection following a single dose.
Public-health relevance
The findings indicate suboptimal vaccination uptake and reduced vaccine effectiveness in the field setting, underscoring the need to expand coverage and investigate reasons for the diminished protection reported here.
Important limitations
Vaccination details for 2008 were unavailable, and the summary relies solely on the supplied single-article abstract/metadata; the original paper is required for decision-grade interpretation.
GIDS interpretation
This article provides historical programmatic context on KFD vaccination outcomes in Karnataka that may aid discoverability of vaccine-effectiveness evidence, but it does not by itself confirm or refute any current surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 12 auditable classifier relationships to diseases, places, topics, and study design.