Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar
PLOS Neglected Tropical Diseases·
- DOI
- 10.1371/journal.pntd.0004827
- PMID
- 27415438
- PMCID
- PMC4945045
- OpenAlex
- W2471878114
- Study type
- Cross-sectional study
- Publisher
- Public Library of Science (PLoS)
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Identifying humid, high-cattle-density environments as higher-risk settings can help target Rift Valley fever surveillance and resource allocation in Madagascar.
Structured evidence summary
Research question
The study asked which environmental factors and areas favor Rift Valley fever transmission to cattle and humans in Madagascar, and which human behaviors are associated with human infection in that setting.
Study design
A national-level cross-sectional serological analysis integrated with a Multiple Factor Analysis of commune-level environments, using Generalized Linear Mixed Models with individual serological status as the response.
Population and setting
Cattle and humans in communes across Madagascar, characterized by heterogeneous environments including humid regions in the western, north-western, and eastern-coast areas suitable for Culex and Anopheles mosquitoes.
Main findings
Cattle and human seroprevalence were both positively associated with humid environments. The findings suggest concomitant vectorial and direct transmission sustaining enzootic circulation, with vectorial transmission likely occurring in both cattle and humans within the identified at-risk humid areas.
Public-health relevance
Identifying humid, high-cattle-density environments as higher-risk settings can help target Rift Valley fever surveillance and resource allocation in Madagascar.
Important limitations
The abstract does not state explicit limitations. This summary is limited to the supplied single-article abstract and metadata and requires the original paper for decision-grade interpretation.
GIDS interpretation
Discoverability context: the article maps environmental risk patterns for Rift Valley fever in Madagascar and may assist in prioritizing locations for surveillance; it does not by itself confirm any live surveillance signal.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.