Low frequency of N-methyl-D-aspartate receptor autoimmunity in tick-borne encephalitis.
PloS one·
- DOI
- 10.1371/journal.pone.0334438
- PMID
- 41082510
- PMCID
- PMC12517480
- OpenAlex
- W4415126348
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The authors note that diagnostic evaluation might be warranted for individuals experiencing delayed neurological decline, though the low prevalence limits broad applicability.
Structured evidence summary
Research question
The investigation sought to quantify how frequently intrathecal anti-NMDAR antibodies develop after tick-borne encephalitis and evaluate their potential link to persistent cognitive difficulties.
Study design
Researchers employed a combined retrospective and prospective cohort approach to examine adult individuals with tick-borne encephalitis.
Population and setting
Participants were drawn from two distinct cohorts and provided archived cerebrospinal fluid specimens during the post-acute recovery phase.
Main findings
Laboratory analysis revealed that only one out of fifty-three participants tested positive for intrathecal anti-NMDAR antibodies, indicating a prevalence near two percent.
Public-health relevance
The authors note that diagnostic evaluation might be warranted for individuals experiencing delayed neurological decline, though the low prevalence limits broad applicability.
Important limitations
The observational framework and reliance on archived specimens limit causal inference, while the absence of longitudinal cognitive tracking leaves clinical implications unresolved.
GIDS interpretation
This article provides measurable incidence data that helps contextualize post-infectious autoimmune phenomena within the broader scientific literature on viral encephalitis sequelae.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 3 auditable classifier relationships to diseases, places, topics, and study design.