Association between fatty liver and risk of liver failure in patients with acute hepatitis B: a retrospective cohort study.
Frontiers in cellular and infection microbiology·
- DOI
- 10.3389/fcimb.2026.1712115
- PMID
- 41674703
- PMCID
- PMC12886492
- OpenAlex
- W7125822052
- Study type
- Cohort study
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
These observational data highlight how metabolic comorbidities intersect with viral hepatitis trajectories, providing contextual information for epidemiological tracking and early risk stratification frameworks.
Structured evidence summary
Research question
What is the relationship between concurrent fatty liver and hepatic outcomes, specifically acute liver failure, among individuals hospitalized for acute hepatitis B?
Study design
The investigation employed a retrospective cohort methodology to examine electronic health records spanning a thirteen-year interval.
Population and setting
The analytical sample consisted of two hundred hospitalized adults diagnosed with acute hepatitis B, stratified by imaging and laboratory results into cohorts with and without fatty liver.
Main findings
Patients presenting with fatty liver demonstrated a markedly elevated frequency of acute liver failure relative to those without the metabolic condition. Adjusted statistical modeling identified the metabolic condition as an independent predictor of this severe complication, whereas viral clearance indicators and seroconversion metrics showed no substantial intergroup disparities. Regional subgroup evaluation revealed a more pronounced correlation between the metabolic condition and liver failure among rural residents.
Public-health relevance
These observational data highlight how metabolic comorbidities intersect with viral hepatitis trajectories, providing contextual information for epidemiological tracking and early risk stratification frameworks.
Important limitations
The retrospective chart review design inherently restricts definitive causal attribution and may be subject to unmeasured confounding variables. Furthermore, the comparatively small number of participants with fatty liver reduces statistical power for evaluating secondary viral clearance endpoints.
GIDS interpretation
This publication supplies observational context regarding metabolic intersections within a defined viral hepatitis cohort, aiding scholarly discovery and background synthesis without implying connection to active outbreak monitoring or real-time surveillance systems.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 8 auditable classifier relationships to diseases, places, topics, and study design.