Role and Contribution of Serological Surveillance in Animals and Exposed Humans to the Study of Zoonotic Influenza Disease Epidemiology: A Scoping Review.
Pathogens (Basel, Switzerland)·
- DOI
- 10.3390/pathogens14080739
- PMID
- 40872249
- PMCID
- PMC12389084
- OpenAlex
- W4412694979
- Study type
- Journal article
- Publisher
- Publisher unavailable
- Article type
- journal-article
- Integrity
- current
Why this research matters now
Expanding antibody-based monitoring programs across interconnected health sectors may improve early identification of cross-species viral circulation and strengthen global outbreak readiness.
Structured evidence summary
Research question
The authors sought to catalog worldwide research on antibody tracking for zoonotic influenza across animal reservoirs and at-risk human cohorts over a seven-year period.
Study design
A systematic scoping review was conducted using PRISMA-ScR protocols to evaluate peer-reviewed literature indexed in PubMed.
Population and setting
Eligible records covered thirty-three nations and documented twenty-five distinct animal taxa, with particular emphasis on agricultural livestock and workers with direct animal contact.
Main findings
Analysis of ninety qualifying papers demonstrated that current antibody monitoring predominantly targets poultry and pigs, leaving wildlife and companion species significantly understudied. While advanced testing formats such as multiplex and nanobody assays emerged, practical adoption continues to encounter operational hurdles.
Public-health relevance
Expanding antibody-based monitoring programs across interconnected health sectors may improve early identification of cross-species viral circulation and strengthen global outbreak readiness.
Important limitations
The authors note that restricting searches to one repository, excluding non-English works, omitting formal study quality evaluation, and encountering high methodological diversity constrain the review's comprehensiveness.
GIDS interpretation
This work functions as a bibliometric and methodological inventory of historical antibody tracking initiatives for avian and swine influenza, offering context on regional coverage and technical evolution without referencing active outbreak monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 10 auditable classifier relationships to diseases, places, topics, and study design.