Determinants of the Seasonal Influenza Vaccination Uptake Among People Aged 50 Years or Above During and After the Pandemic: A Systematic Review
Vaccines·
- DOI
- 10.3390/vaccines14080705
- PMID
- —
- PMCID
- —
- OpenAlex
- W7203627168
- Study type
- Systematic review
- Publisher
- MDPI AG
- Article type
- journal-article
- Integrity
- current
Why this research matters now
The synthesized data offers practical guidance for structuring future immunization initiatives and allocating resources to improve coverage in older adult populations.
Structured evidence summary
Research question
What factors are associated with seasonal influenza vaccination rates in individuals aged 50 and older throughout and following the recent pandemic period?
Study design
A systematic review and meta-analysis aggregating data from fifty peer-reviewed publications spanning late 2019 through early 2026.
Population and setting
Community-dwelling adults aged 50 years and above across diverse geographic locations, with specific analytical attention to the 50–64 age cohort.
Main findings
The aggregated vaccination proportion reached 53 percent, with reduced participation observed among younger seniors, regions lacking complete financial coverage, and the post-pandemic timeframe. Documented factors associated with these rates included fears regarding simultaneous infections, potential cross-vaccine interactions, baseline disease awareness, and safety apprehensions. Economic hurdles and logistical barriers frequently coincided with restricted access in unsponsored healthcare environments.
Public-health relevance
The synthesized data offers practical guidance for structuring future immunization initiatives and allocating resources to improve coverage in older adult populations.
Important limitations
The analysis highlights an insufficient evidence base for the 50–64 age demographic, indicating that current findings may not fully capture the unique behavioral drivers within this specific cohort.
GIDS interpretation
This synthesis provides a historical reference point for evaluating how external health crises and economic structures relate to immunization trends in older populations, establishing a foundational context for retrospective program assessment rather than real-time monitoring.
Related GIDS surveillance
Literature context does not validate, explain, or change a surveillance signal. Exact and contextual relationships are shown separately.
Evidence relationships
This article has 6 auditable classifier relationships to diseases, places, topics, and study design.